Ana Letícia Mores, Carolina Guimarães Bonfim-Alves, Rossana Verónica Mendoza López, Leticia Rodrigues-Oliveira, Natália Rangel Palmier, Bruno Augusto Linhares Almeida Mariz, Cesar Augusto Migliorati, Luiz Paulo Kowalski, Alan Roger Santos-Silva, Thaís Bianca Brandão, Ana Carolina Prado-Ribeiro
{"title":"头颈癌的预后因素：巴西3052例患者的回顾性队列研究","authors":"Ana Letícia Mores, Carolina Guimarães Bonfim-Alves, Rossana Verónica Mendoza López, Leticia Rodrigues-Oliveira, Natália Rangel Palmier, Bruno Augusto Linhares Almeida Mariz, Cesar Augusto Migliorati, Luiz Paulo Kowalski, Alan Roger Santos-Silva, Thaís Bianca Brandão, Ana Carolina Prado-Ribeiro","doi":"10.1111/odi.15196","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Evaluate the sociodemographic, clinical, and lifestyle characteristics at head and neck squamous cell carcinoma (HNSCC) diagnosis and their impact on overall survival (OS) across different anatomical sites.</p><p><strong>Materials and methods: </strong>A retrospective cohort study (2011-2021) at Instituto do Câncer do Estado de São Paulo, involving 3052 HNSCC patients. Survival analyses utilized the Kaplan-Meier method and Cox proportional hazard ratios with 95% confidence intervals, incorporating significant variables from univariate analysis.</p><p><strong>Results: </strong>The five-year OS for all HNSCC sites (n = 3052) was 31.4%, with specific rates of 37.0% for laryngeal cancer (n = 935), 35.8% for oral cancer (n = 762), 26.6% for oropharyngeal cancer (OPC) (n = 1189), and 14.8% for hypopharyngeal cancer (n = 166). HPV-positive OPC had a higher five-year OS (59.3%; n = 127) compared to HPV-negative (35.4%; n = 226). Multivariable analysis identified older age (≥ 70 years) and advanced TNM stage (IV) as adverse prognostic factors for oral cavity, oropharynx, and larynx sites. Male gender was associated with poorer prognosis in the oral cavity, while alcohol consumption was linked to worse outcomes in oropharynx and larynx sites.</p><p><strong>Conclusion: </strong>HNSCC OS remains low at a public cancer center in São Paulo. Older age, advanced tumor stage, and alcohol consumption are independent adverse prognostic factors, particularly in oropharynx and larynx sites.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic Factors in Head and Neck Cancer: A Retrospective Cohort Study of 3052 Patients in Brazil.\",\"authors\":\"Ana Letícia Mores, Carolina Guimarães Bonfim-Alves, Rossana Verónica Mendoza López, Leticia Rodrigues-Oliveira, Natália Rangel Palmier, Bruno Augusto Linhares Almeida Mariz, Cesar Augusto Migliorati, Luiz Paulo Kowalski, Alan Roger Santos-Silva, Thaís Bianca Brandão, Ana Carolina Prado-Ribeiro\",\"doi\":\"10.1111/odi.15196\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Evaluate the sociodemographic, clinical, and lifestyle characteristics at head and neck squamous cell carcinoma (HNSCC) diagnosis and their impact on overall survival (OS) across different anatomical sites.</p><p><strong>Materials and methods: </strong>A retrospective cohort study (2011-2021) at Instituto do Câncer do Estado de São Paulo, involving 3052 HNSCC patients. Survival analyses utilized the Kaplan-Meier method and Cox proportional hazard ratios with 95% confidence intervals, incorporating significant variables from univariate analysis.</p><p><strong>Results: </strong>The five-year OS for all HNSCC sites (n = 3052) was 31.4%, with specific rates of 37.0% for laryngeal cancer (n = 935), 35.8% for oral cancer (n = 762), 26.6% for oropharyngeal cancer (OPC) (n = 1189), and 14.8% for hypopharyngeal cancer (n = 166). HPV-positive OPC had a higher five-year OS (59.3%; n = 127) compared to HPV-negative (35.4%; n = 226). Multivariable analysis identified older age (≥ 70 years) and advanced TNM stage (IV) as adverse prognostic factors for oral cavity, oropharynx, and larynx sites. Male gender was associated with poorer prognosis in the oral cavity, while alcohol consumption was linked to worse outcomes in oropharynx and larynx sites.</p><p><strong>Conclusion: </strong>HNSCC OS remains low at a public cancer center in São Paulo. Older age, advanced tumor stage, and alcohol consumption are independent adverse prognostic factors, particularly in oropharynx and larynx sites.</p>\",\"PeriodicalId\":19615,\"journal\":{\"name\":\"Oral diseases\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-12-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/odi.15196\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/odi.15196","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Prognostic Factors in Head and Neck Cancer: A Retrospective Cohort Study of 3052 Patients in Brazil.
Objective: Evaluate the sociodemographic, clinical, and lifestyle characteristics at head and neck squamous cell carcinoma (HNSCC) diagnosis and their impact on overall survival (OS) across different anatomical sites.
Materials and methods: A retrospective cohort study (2011-2021) at Instituto do Câncer do Estado de São Paulo, involving 3052 HNSCC patients. Survival analyses utilized the Kaplan-Meier method and Cox proportional hazard ratios with 95% confidence intervals, incorporating significant variables from univariate analysis.
Results: The five-year OS for all HNSCC sites (n = 3052) was 31.4%, with specific rates of 37.0% for laryngeal cancer (n = 935), 35.8% for oral cancer (n = 762), 26.6% for oropharyngeal cancer (OPC) (n = 1189), and 14.8% for hypopharyngeal cancer (n = 166). HPV-positive OPC had a higher five-year OS (59.3%; n = 127) compared to HPV-negative (35.4%; n = 226). Multivariable analysis identified older age (≥ 70 years) and advanced TNM stage (IV) as adverse prognostic factors for oral cavity, oropharynx, and larynx sites. Male gender was associated with poorer prognosis in the oral cavity, while alcohol consumption was linked to worse outcomes in oropharynx and larynx sites.
Conclusion: HNSCC OS remains low at a public cancer center in São Paulo. Older age, advanced tumor stage, and alcohol consumption are independent adverse prognostic factors, particularly in oropharynx and larynx sites.
期刊介绍：
Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.
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