IF 8.4 2区 医学 Q1 DERMATOLOGY
Sergio Del Río-Sancho, Stephanie Christen-Zaech, David Alvarez Martinez, Jöri Pünchera, Stéphane Guerrier, Hans J Laubach
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引用次数: 0

摘要

背景:消融点阵光热解是研究伤口愈合的绝佳活体模型。线场共聚焦光学相干断层扫描(LC-OCT)等非侵入性成像设备的出现,通过对皮肤伤口愈合的长期详细监测,增强了这一模型。此外,基于人工智能(AI)的算法通过提供人工无法实现的详细分析,正在彻底改变临床图像的评估:本研究旨在评估 LC-OCT 与人工智能相结合对评估皮肤急性伤口愈合过程的价值:方法:用 CO2 激光对参与研究的志愿者前臂进行点阵消融(7.5 mJ/MTZ)(ClinicalTrials.gov 识别码:NCT05614557)。为了诱导可观察到的伤口愈合差异,两种不同的经批准的硅酮基配方被随机分配到两个测试部位,第三个部位不做处理。在激光治疗后 1 到 7 天的预定时间间隔内获取体内 LC-OCT 图像。使用人工智能算法对这些图像进行了进一步分析:结果:LC-OCT 可视化技术可用于描述伤口愈合过程中皮肤结构重组的特征。人工智能算法的额外整合通过提供对这些干预措施如何改善伤口愈合的更深入了解,极大地增强了对伤口护理干预措施疗效的评估。这对初级保健提供者和皮肤科医生尤其有价值,因为人工智能算法已被证明有助于观察、描述和理解角质形成细胞的行为:结论:人工智能与高分辨率成像的结合是一种很有前途的工具,可用于更好地了解伤口愈合、评估当前伤口护理干预措施的疗效以及详细分析伤口愈合过程中角质细胞的行为:Gov 标识符:NCT05614557。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Line-field confocal optical coherence tomography coupled with artificial intelligence algorithms as tool to investigate wound healing: A prospective, randomized, single-blinded pilot study.

Background: Ablative fractional photothermolysis serves as an excellent in vivo model for studying wound healing. The advent of non-invasive imaging devices, such as line-field confocal optical coherence tomography (LC-OCT), enhances this model by enabling detailed monitoring of skin wound healing over time. Additionally, artificial intelligence (AI)-based algorithms are revolutionizing the evaluation of clinical images by providing detailed analyses that are unfeasible manually.

Objectives: This study aims to assess the value of combining LC-OCT and AI for evaluating the acute wound healing process in the skin.

Methods: The forearms of participating volunteers were ablated with a CO2 laser in a fractional pattern (7.5 mJ/MTZ) (ClinicalTrials.gov identifier: NCT05614557). To induce observable wound healing differences, two different approved silicone-based formulations were randomly assigned to two test sites, with a third site left untreated. In vivo LC-OCT images were obtained at predefined intervals post-laser treatment, ranging from 1 to 7 days. These images were further analysed using AI algorithms.

Results: LC-OCT visualization allows for the characterization of the structural reorganization of the skin during wound healing. The additional integration of AI algorithms significantly enhances the evaluation of the efficacy of wound care interventions by providing a deeper understanding of how these interventions improve wound healing. This is particularly valuable for primary care providers and dermatologists, as AI algorithms have proven useful in observing, characterizing and understanding keratinocyte behaviour.

Conclusions: The combination of AI and high-resolution imaging represents a promising tool for better understanding wound healing, evaluating the efficacy of current wound care interventions and analysing keratinocyte behaviour in detail during the wound healing process.

Clinicaltrials:

Gov identifier: NCT05614557.

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来源期刊
CiteScore
10.70
自引率
8.70%
发文量
874
审稿时长
3-6 weeks
期刊介绍: The Journal of the European Academy of Dermatology and Venereology (JEADV) is a publication that focuses on dermatology and venereology. It covers various topics within these fields, including both clinical and basic science subjects. The journal publishes articles in different formats, such as editorials, review articles, practice articles, original papers, short reports, letters to the editor, features, and announcements from the European Academy of Dermatology and Venereology (EADV). The journal covers a wide range of keywords, including allergy, cancer, clinical medicine, cytokines, dermatology, drug reactions, hair disease, laser therapy, nail disease, oncology, skin cancer, skin disease, therapeutics, tumors, virus infections, and venereology. The JEADV is indexed and abstracted by various databases and resources, including Abstracts on Hygiene & Communicable Diseases, Academic Search, AgBiotech News & Information, Botanical Pesticides, CAB Abstracts®, Embase, Global Health, InfoTrac, Ingenta Select, MEDLINE/PubMed, Science Citation Index Expanded, and others.
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