IF 1.7 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Mehmet Nur Kaya, Emre Tekgöz, Seda Çolak, Özlem Kılıç, Muhammet Çınar, Sedat Yılmaz
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引用次数: 0

摘要

背景:特发性肉芽肿性乳腺炎(IGM特发性肉芽肿性乳腺炎(IGM)是一种良性、罕见的乳腺慢性炎症性疾病。目的:我们设计了这项研究,以评估免疫抑制治疗后 5 年随访期间 IGM 患者的临床状态、缓解持续时间、缓解率和治疗算法:本研究计划在风湿病门诊进行回顾性研究,包括 63 名经活检证实的 IGM 患者。从患者的病历中获取了人口统计学特征、临床表现、治疗方案以及治疗后的无药缓解期:IGM女性患者的平均年龄为(36.4 ± 6.1)岁。所有接受免疫抑制治疗的患者均获得缓解,中位缓解期为 13.9 个月。经过 5 年的随访,未接受药物治疗的中位缓解时间为 46.1 个月。患者的实验室指标和临床表现均有明显改善。所有患者最常用的免疫抑制剂是甲氨蝶呤,其次是硫唑嘌呤:结论:在 5 年的随访期间,未发现 IGM 患者在接受免疫抑制治疗后复发。从治疗管理表中可以看出,大多数患者的病情都得到了缓解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Five-year follow-up of idiopathic granulomatous mastitis.

Background: Idiopathic granulomatous mastitis (IGM) is a benign and rare chronic inflammatory disease of the breast. Although there are various treatment modalities, an ideal treatment algorithm has not been defined.

Aims: We designed this study to evaluate the clinical status, duration of remission, remission rates, and treatment algorithm in patients with IGM during a 5-year follow-up period after immunosuppressive therapy.

Methods: This study was planned retrospectively in the rheumatology outpatient clinic including 63 patients with biopsy-proven IGM. Demographic characteristics, clinical findings, treatment options, and drug-free remission periods after treatment were obtained from the patient's records.

Results: The mean age of female patients with IGM was 36.4 ± 6.1 years. Remission was achieved in all patients receiving immunosuppressive treatment and the median remission period was 13.9 months. After 5 years of follow-up, the median remission time without medication was 46.1 months. There was a significant improvement in the laboratory parameters and clinical findings of the patients. The most preferred immunosuppressive agent in all patients was methotrexate, and the second was azathioprine.

Conclusion: During the 5-year follow-up period, no recurrence after immunosuppressive therapy was detected in IGM patients. As seen in the treatment management chart, methotrexate provided remission in the majority of patients.

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来源期刊
Irish Journal of Medical Science
Irish Journal of Medical Science 医学-医学:内科
CiteScore
3.70
自引率
4.80%
发文量
357
审稿时长
4-8 weeks
期刊介绍: The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.
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