{"title":"Life-threatening dermatoses.","authors":"Caroline A Nelson, Jonathan S Leventhal","doi":"10.1016/j.clindermatol.2024.12.008","DOIUrl":null,"url":null,"abstract":"<p><p>While rare, life-threatening dermatoses encompass various inflammatory, infectious, vasculitic/vasculopathy, paraneoplastic, and neoplastic skin diseases. Complications include skin barrier dysfunction, secondary infection, and internal organ involvement. Skin signs may serve as a critical window into systemic disease. Life-threatening dermatoses are typically associated with \"red flag\" clinical signs or symptoms, which inform the dermatologist about the severity of the disease and mandate a thorough history, review of systems, and physical examination, as well as laboratory evaluation. This contribution highlights severe cutaneous adverse reactions, infections, vasculitides and vasculopathies, and paraneoplastic eruptions. Dermatologists should recognize life-threatening dermatoses and have a framework for rapid diagnosis and management.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinics in dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.clindermatol.2024.12.008","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
While rare, life-threatening dermatoses encompass various inflammatory, infectious, vasculitic/vasculopathy, paraneoplastic, and neoplastic skin diseases. Complications include skin barrier dysfunction, secondary infection, and internal organ involvement. Skin signs may serve as a critical window into systemic disease. Life-threatening dermatoses are typically associated with "red flag" clinical signs or symptoms, which inform the dermatologist about the severity of the disease and mandate a thorough history, review of systems, and physical examination, as well as laboratory evaluation. This contribution highlights severe cutaneous adverse reactions, infections, vasculitides and vasculopathies, and paraneoplastic eruptions. Dermatologists should recognize life-threatening dermatoses and have a framework for rapid diagnosis and management.
期刊介绍：
Clinics in Dermatology brings you the most practical and comprehensive information on the treatment and care of skin disorders. Each issue features a Guest Editor and is devoted to a single timely topic relating to clinical dermatology.
Clinics in Dermatology provides information that is...
• Clinically oriented -- from evaluation to treatment, Clinics in Dermatology covers what is most relevant to you in your practice.
• Authoritative -- world-renowned experts in the field assure the high-quality and currency of each issue by reporting on their areas of expertise.
• Well-illustrated -- each issue is complete with photos, drawings and diagrams to illustrate points and demonstrate techniques.
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