儿童干燥病实验室诊断研究进展。

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-02-01 Epub Date: 2024-12-15 DOI:10.1016/j.cca.2024.120095

Yuemeng Li, Wenxiu He, Yu Zhou, Haotian Chen, Pengyue You, Danni Mu, Yichen Ma, Yumeng Gao, Kaiduo Xu, Haitao Dong, Xinqi Cheng

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引用次数: 0

摘要

儿童干燥病（SjD）是一种罕见的慢性自身免疫性疾病，因其临床表现与成人不同而未被充分认识。因此，需要新的客观指标来补充现有的标志物并协助诊断。本文综述了儿童SjD的发病机制、目前的诊断标准和实验室诊断的研究进展，包括血清学检测、唾液和泪液分析、组织病理学检查以及新兴的感兴趣的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in laboratory diagnosis of Sjogren's disease in children.

Sjogren's disease (SjD) in children is a rare chronic autoimmune disease not fully recognized due to clinical manifestations different from adults. As such, new objective indicators are needed to supplement existing markers and assist in diagnosis. This review summarizes pathogenesis of SjD in children, current diagnostic criteria and research progress in laboratory diagnosis including serologic testing, saliva and tear analysis, histopathological examination as well as emerging markers of interest.

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.