wnt调节疗法用于血脑屏障调节和癌症治疗。

IF 4 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2024-12-16 DOI:10.1021/acs.bioconjchem.4c00537

Pei An, Yang Tong, Rui Mu, Liang Han

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引用次数: 0

摘要

Wnt信号通路在组织发育和体内平衡中具有重要的调控作用。Wnt信号通路的失调与包括癌症和各种脑部疾病在内的许多疾病有关，使该信号通路成为这些疾病的有希望的治疗靶点。本文综述了Wnt信号通路在颅内肿瘤和外周肿瘤血脑屏障（BBB）中的作用，从临床前和临床角度介绍了Wnt调控的治疗方法，包括各种类型的药物和纳米药物作为脑导向药物传递的血脑屏障调节剂和癌症治疗药物，最后讨论了Wnt调控治疗方法的局限性和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Wnt-Regulated Therapeutics for Blood-Brain Barrier Modulation and Cancer Therapy.

The Wnt signaling pathway has a significant regulatory part in tissue development and homeostasis. Dysregulation of the Wnt signaling pathway has been associated with many diseases including cancers and various brain diseases, making this signaling pathway a promising therapeutic target for these diseases. In this review, we describe the roles of the Wnt signaling pathway in the blood-brain barrier (BBB) in intracranial tumors and peripheral tumors, from preclinical and clinical perspectives, introduce Wnt-regulated therapeutics including various types of drugs and nanomedicines as BBB modulators for brain-oriented drug delivery and as therapeutic drugs for cancer treatments, and finally discuss limitations and future perspectives for Wnt-regulated therapeutics.

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.