亚砜胺基促进的硫芳基化制氧鎓苯胺前体：亚砜胺和邻磺酰苯胺的化学选择性合成

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2024-12-16 DOI:10.1021/acs.joc.4c02373

Wang-Liang Chen, Sheng Fang, Jia-Lin Song, Qiong Hu, Shang-Shi Zhang, Bing Shu

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引用次数: 0

摘要

本研究开发了一种以亚砜胺为前驱体的无金属高效合成亚砜胺和邻磺酰苯胺的方法，收率高，化学选择性好。该方法反应条件温和，操作简单，底物范围广，对官能团的耐受性好。此外，还对规模化合成、相关应用及初步机理探索进行了探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Base-Promoted Sulfur Arylation of Sulfenamides to Oxonium Aryne Precursors: Chemoselective Synthesis of Sulfilimines and o-Sulfanylanilines

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Base-Promoted Sulfur Arylation of Sulfenamides to Oxonium Aryne Precursors: Chemoselective Synthesis of Sulfilimines and o-Sulfanylanilines

In this study, a metal-free and efficient method for the synthesis of sulfilimines and o-sulfanylanilines in high yields with excellent chemoselectivities from oxonium aryne precursors with sulfenamides has been developed. This method features mild reaction conditions, simple operations, a general substrate scope, and good tolerance of functional groups. In addition, scale-up synthesis, related applications, and preliminary mechanistic explorations were also investigated.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.