{"title":"使用 Pd/Et3SiH 试剂系统氢化糖烯醚:脱氧糖/糖苷的途径","authors":"Bindu Tiwari, Ram Pratap Pandey, Nazar Hussain","doi":"10.1021/acs.joc.4c02031","DOIUrl":null,"url":null,"abstract":"We have developed a hydrogenation method using Pd(OAc)<sub>2</sub>/Et<sub>3</sub>SiH as a reagent system for sugar enol ethers and their glycosides. This approach is highly effective and applicable to a wide range of glycals and glycosides, achieving yields up to 96% for the corresponding deoxy sugars. Applying standard conditions to various O/C-glycosides resulted in excellent transformation to 2,3-dideoxy glycosides.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"247 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hydrogenation of Sugar Enol-Ethers Using Pd/Et3SiH Reagent System: A Route to Deoxy Sugars/Glycosides\",\"authors\":\"Bindu Tiwari, Ram Pratap Pandey, Nazar Hussain\",\"doi\":\"10.1021/acs.joc.4c02031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We have developed a hydrogenation method using Pd(OAc)<sub>2</sub>/Et<sub>3</sub>SiH as a reagent system for sugar enol ethers and their glycosides. This approach is highly effective and applicable to a wide range of glycals and glycosides, achieving yields up to 96% for the corresponding deoxy sugars. Applying standard conditions to various O/C-glycosides resulted in excellent transformation to 2,3-dideoxy glycosides.\",\"PeriodicalId\":57,\"journal\":{\"name\":\"Journal of Organic Chemistry\",\"volume\":\"247 1\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-12-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Organic Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.joc.4c02031\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.joc.4c02031","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Hydrogenation of Sugar Enol-Ethers Using Pd/Et3SiH Reagent System: A Route to Deoxy Sugars/Glycosides
We have developed a hydrogenation method using Pd(OAc)2/Et3SiH as a reagent system for sugar enol ethers and their glycosides. This approach is highly effective and applicable to a wide range of glycals and glycosides, achieving yields up to 96% for the corresponding deoxy sugars. Applying standard conditions to various O/C-glycosides resulted in excellent transformation to 2,3-dideoxy glycosides.
期刊介绍:
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.