通过钯催化不对称胺化合成手性 2-三氟甲基-4-(四氢喹啉基)-4H-苯并吡喃

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-12-17 DOI:10.1002/adsc.202401422

Bang Zhong Wang, Luyang Sun, Pengyue Zhang, Shuaibo Zhang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou

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引用次数: 0

摘要

报告了一种通过钯催化的 2H-色烯不对称胺化构建手性 4H-色烯骨架的新策略。该方法合成了一系列含有 1,2,3,4-四氢喹啉单元的手性 2-三氟甲基-4H-苯，收率中等至良好，对映选择性极佳，是构建手性 4H-苯骨架的有效补充。

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Synthesis of chiral 2‐trifluoromethyl‐4‐(tetrahydroquinolinyl)‐4H‐chromenes via Pd‐catalyzed asymmetric amination

A new strategy for the construction of chiral 4H‐chromene skeleton via Pd‐catalyzed asymmetric amination of 2H‐chromene was reported. A series of chiral 2‐trifluoromethyl‐4H‐chromenes containing 1,2,3,4‐tetrahydroquinoline unit were synthesized in moderate to good yields with excellent enantioselectivity, the method serves as an effective supplement to the construction of chiral 4H‐chromene skeleton.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.