利用缺电子 Cp*CF3Ir(III) 催化剂和光敏剂实现位点选择性 C(sp3)-H 和可切换 C(sp3)-H/C(sp2)-H 功能化

IF 16.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2024-12-17 DOI:10.1002/anie.202421026

Yuki Hirata, Shunsuke Kimura, Kosuke Higashida, Tatsuhiko Yoshino, Shigeki Matsunaga

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Site‐selective C(sp3)–H and Switchable C(sp3)–H/C(sp2)–H Functionalization Enabled by Electron‐deficient Cp*CF3Ir(III) Catalyst and Photosensitizer

A site‐selective functionalization of a C(sp3)–H bond was achieved in the presence of an intrinsically more reactive C(sp2)–H bond by controlling the orientation of a directing group via a photo‐induced E/Z isomerization of an oxime ether. By combining E/Z isomerization and an electron deficient Cp*CF3Ir(III) catalyst, the scope of oxime ethers in C(sp3)–H functionalization was successfully expanded. Based on this strategy, the order of C–H activation was switchable and successive C(sp3)–H/C(sp2)–H and C(sp2)–H/C(sp3)–H double functionalizations were accomplished to construct densely functionalized structures.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.