N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Spirocyclohexane Oxindoles（N-杂环碳烯催化的螺环己烷吲哚对映体选择性合成物

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-12-17 DOI:10.1002/adsc.202401205

Ye Zhang, Zhoulu Wang, Min Ren, Zhenqian Fu

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引用次数: 0

摘要

通过 N-杂环碳催化α-氰基-β-亚甲基烯酮与靛红衍生烯醛的[4+2]环化反应，成功地构建了具有季碳中心的多种结构不同的螺环己烷羰基吲哚。这种多米诺过程具有广泛的底物耐受性，操作条件温和，生成的产物具有很高的对映选择性。

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N‐Heterocyclic Carbene‐Catalyzed Enantioselective Synthesis of Spirocyclohexane Oxindoles

A variety of structurally diverse spirocyclohexane oxindoles featuring a quaternary carbon centre have been successfully constructed through an N‐heterocyclic carbene‐catalyzed [4+2] annulation of isatin‐derived enals with α cyano‐β‐methylenones. This domino process exhibits a wide substrate tolerance, operates under mild conditions, and yields products with high enantioselectivity.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.