通过越南胡志明市儿童痰中的生物标志物评估个人暴露于空气污染的影响

IF 7.6 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Linh Le Tran, An Le Pham, Minh Duc Do, Quynh Nhat Nguyen, Hieu K.T. Ngo, Hong H.T.C. Le, Vinh Nhu Nguyen, Dung Phung, Peter D. Sly, Phong K. Thai
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引用次数: 0

摘要

了解暴露于空气污染对儿童健康的影响对于制定有效的儿童健康保护政策至关重要。肺泡巨噬细胞黑碳(AMBC)是个人暴露于空气污染的一个指标。因此,我们旨在通过测量肺泡巨噬细胞黑碳面积和痰液中的炎症细胞因子来研究空气污染暴露及其对儿童的影响。我们对 120 名 13-14 岁的儿童进行了痰液诱导,但只有 47 名儿童(39.2%)的痰液样本达到了分析所需的数量和质量。对肺泡巨噬细胞(AMs)进行了观察,并通过显微镜对黑碳(BC)面积进行了量化。参与者填写调查问卷,记录空气污染暴露情况和呼吸道症状。研究了 AMBC 面积与呼吸道症状、暴露变量、细胞因子和肺功能之间的单变量关系。在对潜在混杂因素进行调整后,进行了多变量回归。AMBC 面积的中位数为 0.23 μm2(范围:0.09 至 0.77 μm2)。大多数参与者(87%)都有呼吸道症状病史。AMBC面积与家到学校的距离、住在主干道上以及开窗通风的习惯有关。AMBC面积与呼吸道症状、肺功能或炎症指标(IL-8、TNF-α、IFN-α)之间无明显关联。我们的研究结果支持使用 AMBC 面积作为个人空气污染暴露的生物标志物。AMBC面积与健康结果之间缺乏关联可能是由于研究力量不足,这表明需要进行更广泛的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Assessing the impact of individual exposure to air pollution via biomarkers in sputum of children in Ho Chi Minh City, Vietnam

Assessing the impact of individual exposure to air pollution via biomarkers in sputum of children in Ho Chi Minh City, Vietnam
Understanding the impact of exposure to air pollution on children’s health is critical for developing effective child health protection policies. Alveolar macrophage black carbon (AMBC) provides an indicator of personal exposure to air pollution. Hence, we aimed to examine air pollution exposure and its effects on children by measuring AMBC area and inflammatory cytokines in sputum. Sputum induction was attempted in 120 children aged 13–14 years, but samples of sufficient volume and quality for analysis were only obtained from 47 (39.2%). Alveolar macrophages (AMs) were visualized, and black carbon (BC) area quantified by microscopy. Participants completed questionnaires, recording air pollution exposure and respiratory symptoms. Univariable associations between AMBC area and respiratory symptoms, exposure variables, cytokines, and pulmonary function were examined. Multivariable regression was conducted, adjusting for potential confounders. The median AMBC area was 0.23 μm2 (range: 0.09 to 0.77 μm2). Most participants (87%) reported a history of respiratory symptoms. AMBC area was related to the distance from home to school, living on the main road, and the habit of opening windows for ventilation. No significant associations were seen between AMBC area and respiratory symptoms, lung function, or inflammatory markers (IL-8, TNF-α, IFN-α). Our findings support the use of AMBC area as a biomarker of individual air pollution exposure. The lack of associations between AMBC area and health outcomes is likely due to a lack of study power, indicating more extensive studies are required.
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来源期刊
Environmental Pollution
Environmental Pollution 环境科学-环境科学
CiteScore
16.00
自引率
6.70%
发文量
2082
审稿时长
2.9 months
期刊介绍: Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.
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