Max McLachlan, Brecca Bettcher, Andrew McVea, Alexandra DiFillipo, Matthew Zammit, Lisette LeMerise, Jeremy Rouanet, Julie Price, Dana Tudorascu, Charles Laymon, David Keator, Patrick Lao, Adam M Brickman, Tim Fryer, Sigan Hartley, Beau M Ances, Sterling Johnson, Tobey Betthauser, Charles K Stone, Shahid Zaman, Benjamin Handen, Elizabeth Head, Mark Mapstone, Bradley T Christian
{"title":"使用[11 C]PiB 检测唐氏综合征患者纹状体是淀粉样蛋白负荷的早期准确指标：两种放射性同位素的比较。","authors":"Max McLachlan, Brecca Bettcher, Andrew McVea, Alexandra DiFillipo, Matthew Zammit, Lisette LeMerise, Jeremy Rouanet, Julie Price, Dana Tudorascu, Charles Laymon, David Keator, Patrick Lao, Adam M Brickman, Tim Fryer, Sigan Hartley, Beau M Ances, Sterling Johnson, Tobey Betthauser, Charles K Stone, Shahid Zaman, Benjamin Handen, Elizabeth Head, Mark Mapstone, Bradley T Christian","doi":"10.1101/2024.12.04.24318526","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [ <sup>11</sup> C]PiB PET imaging, which has not been replicated with [ <sup>18</sup> F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.</p><p><strong>Methods: </strong>Longitudinal PiB (n=175 participants) and FBP (n=92 participants) data from the Alzheimer Biomarkers Consortium-Down Syndrome were used to measure cortical and striatal binding. Generalized temporal models for cortical and striatal amyloid accumulation were created using the sampled iterative local approximation (SILA) method.</p><p><strong>Results: </strong>PiB demonstrated greater striatal-to-cortical ratios than FBP. SILA analysis revealed striatal amyloid burden occurs 3.40 (2.39) years earlier than the cortex in PiB. There was no difference between the cortex and striatum in FBP.</p><p><strong>Discussion: </strong>Among adults with Down syndrome, the striatum consistently accumulates amyloid earlier than the cortex when measured with PiB. This suggests the striatum is more sensitive to the onset of PiB PET-detectable amyloid in Down syndrome.</p>","PeriodicalId":94281,"journal":{"name":"medRxiv : the preprint server for health sciences","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11643166/pdf/","citationCount":"0","resultStr":"{\"title\":\"The striatum is an early, accurate indicator of amyloid burden using [ <sup>11</sup> C]PiB in Down syndrome: comparison of two radiotracers.\",\"authors\":\"Max McLachlan, Brecca Bettcher, Andrew McVea, Alexandra DiFillipo, Matthew Zammit, Lisette LeMerise, Jeremy Rouanet, Julie Price, Dana Tudorascu, Charles Laymon, David Keator, Patrick Lao, Adam M Brickman, Tim Fryer, Sigan Hartley, Beau M Ances, Sterling Johnson, Tobey Betthauser, Charles K Stone, Shahid Zaman, Benjamin Handen, Elizabeth Head, Mark Mapstone, Bradley T Christian\",\"doi\":\"10.1101/2024.12.04.24318526\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [ <sup>11</sup> C]PiB PET imaging, which has not been replicated with [ <sup>18</sup> F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.</p><p><strong>Methods: </strong>Longitudinal PiB (n=175 participants) and FBP (n=92 participants) data from the Alzheimer Biomarkers Consortium-Down Syndrome were used to measure cortical and striatal binding. Generalized temporal models for cortical and striatal amyloid accumulation were created using the sampled iterative local approximation (SILA) method.</p><p><strong>Results: </strong>PiB demonstrated greater striatal-to-cortical ratios than FBP. SILA analysis revealed striatal amyloid burden occurs 3.40 (2.39) years earlier than the cortex in PiB. There was no difference between the cortex and striatum in FBP.</p><p><strong>Discussion: </strong>Among adults with Down syndrome, the striatum consistently accumulates amyloid earlier than the cortex when measured with PiB. This suggests the striatum is more sensitive to the onset of PiB PET-detectable amyloid in Down syndrome.</p>\",\"PeriodicalId\":94281,\"journal\":{\"name\":\"medRxiv : the preprint server for health sciences\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11643166/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv : the preprint server for health sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.12.04.24318526\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv : the preprint server for health sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.12.04.24318526","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The striatum is an early, accurate indicator of amyloid burden using [ 11 C]PiB in Down syndrome: comparison of two radiotracers.
Introduction: Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [ 11 C]PiB PET imaging, which has not been replicated with [ 18 F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.
Methods: Longitudinal PiB (n=175 participants) and FBP (n=92 participants) data from the Alzheimer Biomarkers Consortium-Down Syndrome were used to measure cortical and striatal binding. Generalized temporal models for cortical and striatal amyloid accumulation were created using the sampled iterative local approximation (SILA) method.
Results: PiB demonstrated greater striatal-to-cortical ratios than FBP. SILA analysis revealed striatal amyloid burden occurs 3.40 (2.39) years earlier than the cortex in PiB. There was no difference between the cortex and striatum in FBP.
Discussion: Among adults with Down syndrome, the striatum consistently accumulates amyloid earlier than the cortex when measured with PiB. This suggests the striatum is more sensitive to the onset of PiB PET-detectable amyloid in Down syndrome.
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