控制非典型炎性体活化的细菌活力模式。

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-02-01 DOI:10.1016/j.coi.2024.102512

Yuhua Shi , J Magarian Blander

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引用次数: 0

摘要

非典型炎性体在抵御革兰氏阴性细菌的过程中起着重要作用，主要由细菌脂多糖激活。这篇综述探讨了非典型炎症小体激活的共性和区别，它们或由表明细胞入侵的毒力因子活性激活，或由检测到表明无菌组织中存在活细菌的细菌 mRNA 激活。这些炎症小体触发器以及所讨论的其他例子都反映了活细菌独有的特性。新出现的情况强调，非规范炎性体的激活取决于对细菌存活指标的检测，如某些分子的存在或特定过程的活动。根据宿主所面临的感染的特定方面，对组合信号的复杂解读对于炎性体的激活至关重要。对这些信号的解码以及它们在炎症小体激活过程中的交汇将为传染病的干预和治疗提供依据。

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Patterns of bacterial viability governing noncanonical inflammasome activation

Noncanonical inflammasomes are instrumental in defense against Gram-negative bacteria, activated primarily by bacterial lipopolysaccharide. This review examines commonalities and distinctions in noncanonical inflammasome activation either by virulence factor activity indicating cellular invasion or by detection of bacterial mRNA signaling the undesired presence of live bacteria in sterile tissue. These inflammasome triggers, alongside other examples discussed, reflect properties exclusive to live bacteria. The emerging picture underscores noncanonical inflammasome activation hinging on detection of indicators of bacterial viability such as the presence of certain molecules or activity of specific processes. The complex interpretation of combinatorial signals is essential for inflammasome activation according to the specific facet of infection confronting the host. Decoding these signals and their convergence on inflammasome activation will inform interventions and therapies for infectious diseases.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.