在接受丁丙诺啡治疗阿片类药物使用障碍的成年人中,与体重相关的生物心理社会因素的性别差异。

Anna Beth Parlier-Ahmad, Taylor A Ochalek, Melanie K Bean, Susan E Wolver, Salvatore Carbone, Leila Z Islam, F Gerard Moeller, Caitlin E Martin
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引用次数: 0

摘要

导言:阿片类药物使用障碍(MOUD)是治疗阿片类药物使用障碍(OUD)最有效的方法。摄入和继续服用阿片类药物可能会受到健康问题(包括体重增加)和社会因素(如食物不安全)的影响,而这些因素在男性和女性之间存在差异。本研究旨在描述接受丁丙诺啡治疗 OUD 的成年人在体重指数(BMI)和体重相关的人口、社会心理和临床特征方面的性别差异:这项二次分析使用了一项横断面调查和前瞻性病历审查研究中的数据,调查对象为接受丁丙诺啡治疗 OUD 的门诊成年人(女性 77 人,男性 66 人)。调查项目评估了与体重相关的人口统计学和社会心理变量。临床因素通过病历摘要收集。采用χ2、Mann Whitney U和t检验对男女参与者进行比较:大多数参与者为非拉丁裔黑人(69.9%),平均年龄(43.3 ± 12.3)岁。女性中,2.6%的人体重指数为 2,32.5%的人体重指数为 18.5 kg/m2 至 2,35.1%的人体重指数为 25 kg/m2 至 2 或更高。在男性中,1.5%的人的 BMI 值为 2,43.9%的人的 BMI 值为 18.5 kg/m2 至 2,36.4%的人的 BMI 值为 25 kg/m2 至 2 或更高。女性的 BMI 中位数高于男性(27.4 kg/m2 [IQR: 23.3-32.1] vs 25.5 kg/m2 [IQR: 22.2-29.4], P = .041)。女性比男性更有可能失业、接受以营养为基础的公共援助以及服用精神药物:结论:与男性相比,女性的体重指数更高,与体重相关的社会和临床脆弱性也更多。了解这一人群中与体重相关的性别差异对于制定多学科治疗方法非常重要,这些方法可以促进 "MOUD "的接受和持续,并促进 OUD 患者的整体健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex and Gender Differences in Weight-Related Biopsychosocial Factors Among Adults Receiving Buprenorphine for Opioid Use Disorder.

Introduction: Medication for opioid use disorder (MOUD) is the most efficacious treatment for opioid use disorder (OUD). MOUD uptake and continuation may be impacted by health concerns, including weight gain, and social factors, such as food insecurity, that vary between men and women. This study aimed to describe sex and gender differences in body mass index (BMI) and weight-related demographic, psychosocial, and clinical characteristics among adults receiving buprenorphine for OUD.

Methods: This secondary analysis used data from a cross-sectional survey and prospective medical record review study among adults (n = 77 female, n = 66 male) engaged in outpatient treatment receiving buprenorphine for OUD. Survey items assessed weight-related demographic and psychosocial variables. Clinical factors were collected via chart abstraction. Comparisons between male and female participants were made using χ2, Mann Whitney U, and t-tests.

Results: Most participants were non-Latinx, Black (69.9%), with a mean age of 43.3 ± 12.3 years. Among females, 2.6% had a BMI <18.5 kg/m2, 32.5% had a BMI from 18.5 kg/m2 to <25 kg/m2, 35.1% had a BMI from 25 kg/m2 to <30, and 29.9% had a BMI of 30 kg/m2 or higher. Among males, 1.5% had a BMI <18.5 kg/m2, 43.9% had a BMI from 18.5 kg/m2 to <25 kg/m2, 36.4% had a BMI from 25 kg/m2 to <30, and 18.2% had a BMI of 30 kg/m2 or higher. Females had a higher median BMI than males (27.4 kg/m2 [IQR: 23.3-32.1] vs 25.5 kg/m2 [IQR: 22.2-29.4], P = .041). Females were more likely than males to be unemployed, receive nutrition-based public assistance, and be prescribed psychotropic medication.

Conclusions: Females had a greater BMI than males and experienced more weight-related social and clinical vulnerabilities. Understanding weight-related sex and gender differences in this population is important for informing multidisciplinary treatment approaches that promote MOUD uptake and continuation and center overall health in people with OUD.

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