Li Shu , Pianpian Fan , Yuanzhi Chen , Weifeng Tang , Zhiwei Liu , Zhong-Cheng Luo , Fengxiu Ouyang
{"title":"出生后 6 个月婴儿尿液中 18 种环境酚的浓度及其与喂养模式的关系。","authors":"Li Shu , Pianpian Fan , Yuanzhi Chen , Weifeng Tang , Zhiwei Liu , Zhong-Cheng Luo , Fengxiu Ouyang","doi":"10.1016/j.chemosphere.2024.143954","DOIUrl":null,"url":null,"abstract":"<div><div>Environmental phenols are a group of typical endocrine disruptors, and widely detectable in human breast milk and infant formulas. However, exposures data are scarce in early infancy, a particularly sensitive period to environmental pollutants exposures. We aimed to prospectively assess urinary concentrations of eighteen environmental phenols in infants from birth to 6 months of age and their associations with feeding patterns (breastfeeding, formula and mixed-feeding). This study included 197 mother-infant pairs. Urinary concentrations of six parabens (PBs), seven bisphenols, four benzophenones (BPs) and triclosan were measured in infants at the ages of 3 days, 42 days, 3 and 6 months by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Multivariable linear regression models were applied to evaluate the associations between infant feeding types and urinary phenol concentrations in log<sub>10</sub>-transformed scale. The detection rates of bisphenol A and S, methyl 4-hydroxybenzoate (MeP), ethyl 4-hydroxybenzoate (EtP), and propyl 4-hydroxybenzoate (PrP) were persistently high (ranged 48.7%–100.0%) across all ages (3 days, 42 days, 3 and 6 months). The detection rates of bisphenol P, B and AP were high (ranged 76.9%–95.9%) at age 3 days, and lower (14.4%–88.0%) at later ages. Compared to exclusive breastfeeding, mixed feeding was associated with 0.32 (95% <em>CI</em>: 0.01, 0.62, <em>p</em> < 0.05) higher log (BPA) (μg/g creatinine) at 42 days, 0.69 (0.03, 1.35) higher log (TCS) (μg/g creatinine) at 3 months, 0.54 (0.08, 1.00) higher log (EtP) (μg/g creatinine) at 6 months; formula feeding was associated with 1.30 (0.59, 2.00) and 0.91 (0.22, 1.60) higher log (BPB) (μg/g creatinine) at the age of 42 days and 3 months respectively, 1.19 (0.003–2.37) higher log (BPP) and 0.95 (0.27–1.64) higher log (BPS) (μg/g creatinine) at 3 months. In conclusion, exposures to BPA and its analogs, and parabens (MeP, EtP, and PrP) were extensive in early postnatal life of infants. Breastfeeding might be a safer form of feeding for infants against exposure to some phenols.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"370 ","pages":"Article 143954"},"PeriodicalIF":8.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Urinary concentrations of eighteen environmental phenols and the associations with feeding pattern in infants in the first 6 months of life\",\"authors\":\"Li Shu , Pianpian Fan , Yuanzhi Chen , Weifeng Tang , Zhiwei Liu , Zhong-Cheng Luo , Fengxiu Ouyang\",\"doi\":\"10.1016/j.chemosphere.2024.143954\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Environmental phenols are a group of typical endocrine disruptors, and widely detectable in human breast milk and infant formulas. However, exposures data are scarce in early infancy, a particularly sensitive period to environmental pollutants exposures. We aimed to prospectively assess urinary concentrations of eighteen environmental phenols in infants from birth to 6 months of age and their associations with feeding patterns (breastfeeding, formula and mixed-feeding). This study included 197 mother-infant pairs. Urinary concentrations of six parabens (PBs), seven bisphenols, four benzophenones (BPs) and triclosan were measured in infants at the ages of 3 days, 42 days, 3 and 6 months by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Multivariable linear regression models were applied to evaluate the associations between infant feeding types and urinary phenol concentrations in log<sub>10</sub>-transformed scale. The detection rates of bisphenol A and S, methyl 4-hydroxybenzoate (MeP), ethyl 4-hydroxybenzoate (EtP), and propyl 4-hydroxybenzoate (PrP) were persistently high (ranged 48.7%–100.0%) across all ages (3 days, 42 days, 3 and 6 months). The detection rates of bisphenol P, B and AP were high (ranged 76.9%–95.9%) at age 3 days, and lower (14.4%–88.0%) at later ages. Compared to exclusive breastfeeding, mixed feeding was associated with 0.32 (95% <em>CI</em>: 0.01, 0.62, <em>p</em> < 0.05) higher log (BPA) (μg/g creatinine) at 42 days, 0.69 (0.03, 1.35) higher log (TCS) (μg/g creatinine) at 3 months, 0.54 (0.08, 1.00) higher log (EtP) (μg/g creatinine) at 6 months; formula feeding was associated with 1.30 (0.59, 2.00) and 0.91 (0.22, 1.60) higher log (BPB) (μg/g creatinine) at the age of 42 days and 3 months respectively, 1.19 (0.003–2.37) higher log (BPP) and 0.95 (0.27–1.64) higher log (BPS) (μg/g creatinine) at 3 months. In conclusion, exposures to BPA and its analogs, and parabens (MeP, EtP, and PrP) were extensive in early postnatal life of infants. Breastfeeding might be a safer form of feeding for infants against exposure to some phenols.</div></div>\",\"PeriodicalId\":276,\"journal\":{\"name\":\"Chemosphere\",\"volume\":\"370 \",\"pages\":\"Article 143954\"},\"PeriodicalIF\":8.1000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemosphere\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0045653524028625\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemosphere","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0045653524028625","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Urinary concentrations of eighteen environmental phenols and the associations with feeding pattern in infants in the first 6 months of life
Environmental phenols are a group of typical endocrine disruptors, and widely detectable in human breast milk and infant formulas. However, exposures data are scarce in early infancy, a particularly sensitive period to environmental pollutants exposures. We aimed to prospectively assess urinary concentrations of eighteen environmental phenols in infants from birth to 6 months of age and their associations with feeding patterns (breastfeeding, formula and mixed-feeding). This study included 197 mother-infant pairs. Urinary concentrations of six parabens (PBs), seven bisphenols, four benzophenones (BPs) and triclosan were measured in infants at the ages of 3 days, 42 days, 3 and 6 months by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Multivariable linear regression models were applied to evaluate the associations between infant feeding types and urinary phenol concentrations in log10-transformed scale. The detection rates of bisphenol A and S, methyl 4-hydroxybenzoate (MeP), ethyl 4-hydroxybenzoate (EtP), and propyl 4-hydroxybenzoate (PrP) were persistently high (ranged 48.7%–100.0%) across all ages (3 days, 42 days, 3 and 6 months). The detection rates of bisphenol P, B and AP were high (ranged 76.9%–95.9%) at age 3 days, and lower (14.4%–88.0%) at later ages. Compared to exclusive breastfeeding, mixed feeding was associated with 0.32 (95% CI: 0.01, 0.62, p < 0.05) higher log (BPA) (μg/g creatinine) at 42 days, 0.69 (0.03, 1.35) higher log (TCS) (μg/g creatinine) at 3 months, 0.54 (0.08, 1.00) higher log (EtP) (μg/g creatinine) at 6 months; formula feeding was associated with 1.30 (0.59, 2.00) and 0.91 (0.22, 1.60) higher log (BPB) (μg/g creatinine) at the age of 42 days and 3 months respectively, 1.19 (0.003–2.37) higher log (BPP) and 0.95 (0.27–1.64) higher log (BPS) (μg/g creatinine) at 3 months. In conclusion, exposures to BPA and its analogs, and parabens (MeP, EtP, and PrP) were extensive in early postnatal life of infants. Breastfeeding might be a safer form of feeding for infants against exposure to some phenols.
期刊介绍:
Chemosphere, being an international multidisciplinary journal, is dedicated to publishing original communications and review articles on chemicals in the environment. The scope covers a wide range of topics, including the identification, quantification, behavior, fate, toxicology, treatment, and remediation of chemicals in the bio-, hydro-, litho-, and atmosphere, ensuring the broad dissemination of research in this field.