{"title":"代谢综合征对胃疾病的因果影响：单变量和多变量孟德尔随机化。","authors":"Bowen Li, Jianguo Xu, Qingyong Zheng, Jie Gao, Qian Ren, Yongning Zhou","doi":"10.1210/clinem/dgae843","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Metabolic syndrome (MetS) has been associated with various gastrointestinal disorders, but the causal relationships between MetS components and gastric disorders remain unclear. Previous observational studies are limited by confounding factors and reverse causation.</p><p><strong>Objectives: </strong>This study aimed to investigate the causal effects of MetS components, including fasting blood glucose (FBG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs), waist circumference (WC), and hypertension, on the risks of chronic gastritis, benign gastric tumors, and gastric cancer using mendelian randomization (MR) analyses.</p><p><strong>Methods: </strong>Univariable 2-sample mendelian randomization (TSMR) and multivariable mendelian randomization (MVMR) analyses were employed to evaluate the independent and combined effects of MetS components on gastric disorders. The primary MR method used was the random effects inverse-variance weighted (IVW) approach.</p><p><strong>Results: </strong>Univariable TSMR analysis identified statistically significant associations between elevated TGs (odds ratio [OR] = 1.223, 95% CI, 1.011-1.480; P = .0386) and reduced HDL-C (OR = 0.833, 95% CI, 0.701-0.989; P = .037) with an increased risk of benign gastric tumors. However, these associations were not confirmed by MVMR for TGs (OR = 1.187, 95% CI, 0.891-1.581; P = .2408) or HDL-C (OR = 0.989, 95% CI, 0.758-1.289; P = .932). Both TSMR (OR = 0.585, 95% CI, 0.411-0.831; P = .003) and MVMR (OR = 0.558, 95% CI, 0.334-0.930; P = .025) indicated that hypertension is associated with a reduced risk of gastric cancer. No statistically significant associations were found for other MetS components and gastric disorders.</p><p><strong>Conclusion: </strong>The findings suggest that specific MetS components, such as TGs and HDL-C, may affect the risk of benign gastric tumors, while hypertension might reduce the risk of gastric cancer. This study highlights the need for further research to understand the underlying mechanisms and potential indirect effects between MetS components and gastric disorders.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"e2498-e2509"},"PeriodicalIF":5.0000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Causal Effects of Metabolic Syndrome on Gastric Disorders: Univariable and Multivariable Mendelian Randomization.\",\"authors\":\"Bowen Li, Jianguo Xu, Qingyong Zheng, Jie Gao, Qian Ren, Yongning Zhou\",\"doi\":\"10.1210/clinem/dgae843\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>Metabolic syndrome (MetS) has been associated with various gastrointestinal disorders, but the causal relationships between MetS components and gastric disorders remain unclear. Previous observational studies are limited by confounding factors and reverse causation.</p><p><strong>Objectives: </strong>This study aimed to investigate the causal effects of MetS components, including fasting blood glucose (FBG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs), waist circumference (WC), and hypertension, on the risks of chronic gastritis, benign gastric tumors, and gastric cancer using mendelian randomization (MR) analyses.</p><p><strong>Methods: </strong>Univariable 2-sample mendelian randomization (TSMR) and multivariable mendelian randomization (MVMR) analyses were employed to evaluate the independent and combined effects of MetS components on gastric disorders. The primary MR method used was the random effects inverse-variance weighted (IVW) approach.</p><p><strong>Results: </strong>Univariable TSMR analysis identified statistically significant associations between elevated TGs (odds ratio [OR] = 1.223, 95% CI, 1.011-1.480; P = .0386) and reduced HDL-C (OR = 0.833, 95% CI, 0.701-0.989; P = .037) with an increased risk of benign gastric tumors. However, these associations were not confirmed by MVMR for TGs (OR = 1.187, 95% CI, 0.891-1.581; P = .2408) or HDL-C (OR = 0.989, 95% CI, 0.758-1.289; P = .932). Both TSMR (OR = 0.585, 95% CI, 0.411-0.831; P = .003) and MVMR (OR = 0.558, 95% CI, 0.334-0.930; P = .025) indicated that hypertension is associated with a reduced risk of gastric cancer. No statistically significant associations were found for other MetS components and gastric disorders.</p><p><strong>Conclusion: </strong>The findings suggest that specific MetS components, such as TGs and HDL-C, may affect the risk of benign gastric tumors, while hypertension might reduce the risk of gastric cancer. This study highlights the need for further research to understand the underlying mechanisms and potential indirect effects between MetS components and gastric disorders.</p>\",\"PeriodicalId\":50238,\"journal\":{\"name\":\"Journal of Clinical Endocrinology & Metabolism\",\"volume\":\" \",\"pages\":\"e2498-e2509\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Endocrinology & Metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1210/clinem/dgae843\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Endocrinology & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1210/clinem/dgae843","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
目的：本研究旨在通过孟德尔随机化（MR）分析，探讨代谢综合征（MetS）组成部分，包括空腹血糖（FBG）、高密度脂蛋白胆固醇（HDL- c）、甘油三酯（TG）、腰围（WC）和高血压对慢性胃炎、良性胃肿瘤和胃癌风险的因果关系。方法：采用单变量双样本孟德尔随机化（TSMR）和多变量孟德尔随机化（MVMR）分析，评价代谢产物成分对胃疾病的独立和联合作用。使用的主要MR方法是随机效应逆方差加权（IVW）方法。结果：单变量TSMR分析发现TG升高（OR = 1.223, 95% CI: 1.011-1.480, p = 0.0386）和HDL-C降低（OR = 0.833, 95% CI: 0.701-0.989, p = 0.037）与胃良性肿瘤风险增加之间存在显著关联。然而，这些相关性没有被TG （OR = 1.187, 95% CI: 0.891-1.581, p = 0.2408）或HDL-C （OR = 0.989, 95% CI: 0.758-1.289, p = 0.932）的MVMR证实。TSMR （OR = 0.585, 95% CI: 0.411-0.831, p = 0.003）和MVMR （OR = 0.558, 95% CI: 0.334-0.930, p = 0.025）均表明高血压与胃癌风险降低相关。没有发现其他代谢代谢成分与胃疾病有显著关联。结论：研究结果提示，特定的MetS成分如TG和HDL-C可能影响胃良性肿瘤的发生风险，而高血压可能降低胃癌的发生风险。这项研究强调了进一步研究的必要性，以了解MetS成分与胃疾病之间的潜在机制和潜在间接影响。
Causal Effects of Metabolic Syndrome on Gastric Disorders: Univariable and Multivariable Mendelian Randomization.
Context: Metabolic syndrome (MetS) has been associated with various gastrointestinal disorders, but the causal relationships between MetS components and gastric disorders remain unclear. Previous observational studies are limited by confounding factors and reverse causation.
Objectives: This study aimed to investigate the causal effects of MetS components, including fasting blood glucose (FBG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs), waist circumference (WC), and hypertension, on the risks of chronic gastritis, benign gastric tumors, and gastric cancer using mendelian randomization (MR) analyses.
Methods: Univariable 2-sample mendelian randomization (TSMR) and multivariable mendelian randomization (MVMR) analyses were employed to evaluate the independent and combined effects of MetS components on gastric disorders. The primary MR method used was the random effects inverse-variance weighted (IVW) approach.
Results: Univariable TSMR analysis identified statistically significant associations between elevated TGs (odds ratio [OR] = 1.223, 95% CI, 1.011-1.480; P = .0386) and reduced HDL-C (OR = 0.833, 95% CI, 0.701-0.989; P = .037) with an increased risk of benign gastric tumors. However, these associations were not confirmed by MVMR for TGs (OR = 1.187, 95% CI, 0.891-1.581; P = .2408) or HDL-C (OR = 0.989, 95% CI, 0.758-1.289; P = .932). Both TSMR (OR = 0.585, 95% CI, 0.411-0.831; P = .003) and MVMR (OR = 0.558, 95% CI, 0.334-0.930; P = .025) indicated that hypertension is associated with a reduced risk of gastric cancer. No statistically significant associations were found for other MetS components and gastric disorders.
Conclusion: The findings suggest that specific MetS components, such as TGs and HDL-C, may affect the risk of benign gastric tumors, while hypertension might reduce the risk of gastric cancer. This study highlights the need for further research to understand the underlying mechanisms and potential indirect effects between MetS components and gastric disorders.
期刊介绍：
The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.
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