Caregiver Medication Information Needs and Medication Management Challenges in Pediatric Cancer: A Systematic Review.

Background: The objective of this systematic review was to identify the medication information needs and preferences of caregivers of children with cancer and explore the medication management challenges these caregivers experienced. Method: We conducted a systematic search of three databases (Cumulative Index to Nursing and Allied Health Literature, Embase, and Medline) for studies published from database inception to February 27, 2024, and assessed the medication information needs of caregivers of children with cancer. The methodological quality of qualitative studies was assessed using the Critical Appraisal Skills Programme Qualitative Research Checklist. Quantitative and mixed-methods studies were appraised using the Mixed Methods Appraisal Tool. Results: A total of 813 articles were retrieved using our search criteria, of which 13 met the eligibility criteria. Three overarching categories were identified: caregiver medication information needs and preferences, medication management concerns and challenges, and medication management strategies. Most studies focused on the needs and concerns of mothers of children with acute lymphoblastic leukemia in high-income countries, leaving a knowledge gap in relation to the perspectives of other caregivers across a broader range of malignancies. Discussion: This systematic review underscores the critical medication information needs of caregivers managing chemotherapy for children with cancer. Caregivers require tailored, accessible information throughout the treatment trajectory to effectively manage medication regimens and mitigate potential errors. Addressing these needs through comprehensive education strategies is essential for enhancing caregiver self-efficacy and improving overall patient outcomes in pediatric oncology.