将不同类型的童年逆境和首次发病的精神病与大脑各区域皮质厚度的关系三角化。

IF 5.9 2区 医学 Q1 PSYCHIATRY
Natalia E Fares-Otero, Norma Verdolini, Helena Melero, Pablo Andrés-Camazón, Enric Vilajosana, Vito Cavone, Borja García-Bueno, Marta Rapado-Castro, Ana Izquierdo, David Martín-Hernández, Pablo Mola Cárdenes, Itziar Leal, Monica Dompablo, Ana Ortiz-Tallo, Isabel Martinez-Gras, Ainoa Muñoz-Sanjose, Carmen Loeck de Lapuerta, Roberto Rodriguez-Jimenez, Marina Díaz Marsá, Maria-Fe Bravo-Ortiz, Angela Ibañez, Enrique Baca-García, Eduard Vieta, J L Ayuso-Mateos, Norberto Malpica, Celso Arango, Covadonga M Díaz-Caneja, Joaquim Radua
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引用次数: 0

摘要

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Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions.

Background: Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied.

Methods: One-hundred sixteen individuals with FEP (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) and 98 healthy controls (HCs) (mean age = 24.4 ± 6.2 years, 43% females) reported the presence/absence of CA <17 years using an adapted version of the Childhood Experience of Care and Abuse (CECA.Q) and the Retrospective Bullying Questionnaire (RBQ) and underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used to assess associations between brain maps of CA and FEP effects. General linear models (GLMs) were performed to assess the interaction effects of CA and FEP on CT.

Results: Eighty-three individuals with FEP and 83 HCs reported exposure to at least one CA. CT alterations in FEP were similar to those found in participants exposed to separation from parents, bullying, parental discord, household poverty, and sexual abuse (r = 0.50 to 0.25). Exposure to neglect (β = -0.24, 95% CI [-0.37 to -0.12], p = 0.016) and overall maltreatment (β = -0.13, 95% CI [-0.20 to -0.06], p = 0.043) were associated with cortical thinning in the right medial orbitofrontal region.

Conclusions: Cortical alterations in individuals with FEP are similar to those observed in the context of socio-environmental adversity. Neglect and maltreatment may contribute to CT reductions in FEP. Our findings provide new insights into the specific neurobiological effects of CA in early psychosis.

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来源期刊
Psychological Medicine
Psychological Medicine 医学-精神病学
CiteScore
11.30
自引率
4.30%
发文量
711
审稿时长
3-6 weeks
期刊介绍: Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.
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