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IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-16 DOI:10.1080/14786419.2024.2440930

Ibrahim A Saleh, Wael M Elsayed, Taha A Hussien, Abdelsamed I Elshamy, Tarik A Mohamed, Mohamed-Elamir F Hegazy

引用次数: 0

摘要

从矢车菊的 CH2Cl2:MeOH 有机提取物中分离出了一种新的卡迪那烷型倍半萜葡萄糖苷、10α-羟基、1α(H)、6β(H)、7β(H)、8β(H)-cadinane-4-en-8-O-β-D-葡萄糖苷 (1) 以及两种已知的类似物 [sinaicin (2)- linichlorinA (3)]。根据光谱数据，包括一维和二维核磁共振以及 HRMS，确定了所有分离化合物的化学结构。利用 Colo-205（结直肠癌）、HepG2（肝细胞癌）和 MCF-7（乳腺癌）癌细胞系测试分离化合物的细胞毒性潜力（1-3）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A new cadinane-type sesquiterpenoid glucoside from Centaurea alexandrina.

A new cadinane-type sesquiterpene glucoside, 10α-hydroxy, 1α(H), 6β(H), 7β(H), 8β(H)-cadinane-4-en-8-O-β-D-glucoside (1) as well as, 2 known analogues [sinaicin (2)- linichlorinA (3)], were isolated from the CH₂Cl₂:MeOH organic extract of Centaurea alexandrina. Chemical structures of all isolated compounds were established depending upon the spectroscopic data including, 1D and 2D NMR and HRMS. Colo-205 (colorectal cancer), HepG2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) and cancer cell lines were used to test the cytotoxic potential of the isolated compounds (1-3).

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.