CsxWO3@NBs 作为一种多成像引导的光热/光动力联合疗法平台用于治疗肝细胞癌。

IF 6.6 2区 医学 Q1 NANOSCIENCE & NANOTECHNOLOGY
International Journal of Nanomedicine Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S484694
Chunyue Wang, Xiaodong Wang, Yuhang Tian, Huimin Tian, Yichi Chen, Bolin Wu, Wen Cheng
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引用次数: 0

摘要

目的:有效的癌症治疗有赖于临床成像技术的精确应用,以准确治疗肿瘤。其中一项极具代表性的技术是多成像引导光疗。这项工作介绍了一种创新的治疗药物,它结合了近红外(NIR)辐照诱导的光动力疗法(PDT)和光热疗法(PTT)来治疗恶性肿瘤。此外,它还可用作 X 射线计算机断层扫描(CT)成像和对比度增强超声波(CEUS)的对比物质,以帮助实施治疗:方法:铯钨青铜纳米气泡(CsxWO3@NBs)是通过水控溶热合成和磷脂薄膜水合构建的。利用动态光散射、透射电子显微镜和 X 射线光电子能谱等多种方法分析和描述了纳米颗粒的尺寸、形状和化学特性。本研究采用肝癌细胞系 HepG2 和 HUH7 进行体外实验,并使用异种移植小鼠模型评估其抗肿瘤效果。研究人员进行了一系列体外和体内试验,以评估光动力疗法和光热疗法相结合的效果,并使用了CEUS和CT成像技术:结果:在激光照射下,CsxWO3@NBs 具有光热效应并产生活性氧(ROS),从而实现了有效的光热和光动力联合疗法。联合治疗后,肝癌细胞的活性和侵袭能力明显减弱,肿瘤的发展速度明显降低,生物毒性水平较低。此外,CsxWO3@NBs 还可作为 CT 成像剂和对比增强超声剂:结论:CsxWO3@NBs 是一种很有前景的用于图像引导癌症治疗的治疗剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CsxWO3@NBs as a Multi-Image Guided Photothermal/Photodynamic Combination Therapy Platform for the Treatment of Hepatocellular Carcinoma.

Purpose: Effective cancer treatment relies on the precise deployment of clinical imaging techniques to accurately treat tumors. One highly representative technology among these is multi-imaging guided phototherapy. This work introduces a new and innovative theranostic drug that combines near-infrared (NIR) irradiation-induced photodynamic therapy (PDT) and photothermal therapy (PTT) to treat malignancies. Moreover, it can be utilized as a contrasting substance for X-ray computed tomography (CT) imaging and contrast-enhanced ultrasound (CEUS) to aid in the administration of therapy.

Methods: Cesium tungsten bronze nanobubbles (CsxWO3@NBs) were constructed via a water-controlled solvothermal synthesis and thin film hydration of phospholipid. Various methods, including dynamic light scattering, transmission electron microscopy, and X-ray photoelectron spectroscopy, were used to analyze and describe the size, shape, and chemical characteristics of the nanoparticles. In this study, hepatoma cell lines HepG2 and HUH7 were employed in vitro, and xenotransplantation mouse models were used to assess their antitumor effects. A series of in vitro and in vivo trials were conducted to assess the effectiveness of combining photodynamic and photothermal therapies, as well as using CEUS and CT imaging.

Results: The CsxWO3@NBs exhibit photothermal effects and the generation of reactive oxygen species (ROS) under laser irradiation, thereby enabling effective photothermal and photodynamic combinatorial therapy. Following combined treatment, the activity and invasive capacity of hepatocellular carcinoma cells were markedly diminished, the development rate of the tumor was noticeably reduced, and the level of biological toxicity was low. Additionally, CsxWO3@NBs possess the capacity to serve as both a CT imaging agent and a contrast-enhanced ultrasound agent.

Conclusion: CsxWO3@NBs represent a promising theranostic agent for image-guided cancer therapy.

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来源期刊
International Journal of Nanomedicine
International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY
CiteScore
14.40
自引率
3.80%
发文量
511
审稿时长
1.4 months
期刊介绍: The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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