{"title":"牛至提取物在减轻乙醇引起的大鼠工作记忆损伤和海马氧化应激方面具有良好的治疗潜力。","authors":"Maryam Aliabadi, Farhad Valizadegan, Bagher Seyedalipour, Sahar Yaqubi, Ehsan Nazifi","doi":"10.1080/09603123.2024.2440898","DOIUrl":null,"url":null,"abstract":"<p><p>This study explored the therapeutic potential hydroalcoholic extract derived from Origanum vulgare leaf in mitigating ethanol-induced working memory impairments and hippocampal oxidative stress in rats. Eight groups, including controls, ethanol-exposed rats, and those treated with extract (100, 200, and 300 mg/kg) alone or combined with ethanol, were assessed using the radial arm maze (RAM) for behavioral tests. Ethanol increased working memory errors and time spent in error zones, effects notably reduced by the extract, especially at 300 mg/kg dose (P≤0.001). Biochemical tests showed ethanol suppressed catalase (CAT), superoxide dismutase (SOD), and acetylcholinesterase (AChE) activities within the hippocampus and cortex. while the extract elevated CAT and SOD activities and reduced AChE activity. These results suggest the extract's neuroprotective properties, including oxidative stress reduction and neurotransmitter modulation, which mitigate ethanol-induced hippocampal damage. This highlights Origanum vulgare extract potential as a therapeutic adjunct for memory deficits and oxidative stress-related conditions.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-14"},"PeriodicalIF":2.2000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A promising therapeutic potential of <i>Origanum vulgare</i> extract in mitigating ethanol-induced working memory impairments and hippocampal oxidative stress in rats.\",\"authors\":\"Maryam Aliabadi, Farhad Valizadegan, Bagher Seyedalipour, Sahar Yaqubi, Ehsan Nazifi\",\"doi\":\"10.1080/09603123.2024.2440898\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study explored the therapeutic potential hydroalcoholic extract derived from Origanum vulgare leaf in mitigating ethanol-induced working memory impairments and hippocampal oxidative stress in rats. Eight groups, including controls, ethanol-exposed rats, and those treated with extract (100, 200, and 300 mg/kg) alone or combined with ethanol, were assessed using the radial arm maze (RAM) for behavioral tests. Ethanol increased working memory errors and time spent in error zones, effects notably reduced by the extract, especially at 300 mg/kg dose (P≤0.001). Biochemical tests showed ethanol suppressed catalase (CAT), superoxide dismutase (SOD), and acetylcholinesterase (AChE) activities within the hippocampus and cortex. while the extract elevated CAT and SOD activities and reduced AChE activity. These results suggest the extract's neuroprotective properties, including oxidative stress reduction and neurotransmitter modulation, which mitigate ethanol-induced hippocampal damage. This highlights Origanum vulgare extract potential as a therapeutic adjunct for memory deficits and oxidative stress-related conditions.</p>\",\"PeriodicalId\":14039,\"journal\":{\"name\":\"International Journal of Environmental Health Research\",\"volume\":\" \",\"pages\":\"1-14\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-12-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Environmental Health Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/09603123.2024.2440898\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Environmental Health Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09603123.2024.2440898","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
A promising therapeutic potential of Origanum vulgare extract in mitigating ethanol-induced working memory impairments and hippocampal oxidative stress in rats.
This study explored the therapeutic potential hydroalcoholic extract derived from Origanum vulgare leaf in mitigating ethanol-induced working memory impairments and hippocampal oxidative stress in rats. Eight groups, including controls, ethanol-exposed rats, and those treated with extract (100, 200, and 300 mg/kg) alone or combined with ethanol, were assessed using the radial arm maze (RAM) for behavioral tests. Ethanol increased working memory errors and time spent in error zones, effects notably reduced by the extract, especially at 300 mg/kg dose (P≤0.001). Biochemical tests showed ethanol suppressed catalase (CAT), superoxide dismutase (SOD), and acetylcholinesterase (AChE) activities within the hippocampus and cortex. while the extract elevated CAT and SOD activities and reduced AChE activity. These results suggest the extract's neuroprotective properties, including oxidative stress reduction and neurotransmitter modulation, which mitigate ethanol-induced hippocampal damage. This highlights Origanum vulgare extract potential as a therapeutic adjunct for memory deficits and oxidative stress-related conditions.
期刊介绍:
International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.