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IF 3.2 3区医学 Q2 PSYCHIATRY

Frontiers in Psychiatry Pub Date : 2024-11-29 eCollection Date: 2024-01-01 DOI:10.3389/fpsyt.2024.1481795

Kristy L Meads, Steve Huettner, Dexter Amata, Hailey Johnson, Jaime K Devine, Shenali Warnakulasuriya, Keith R Murphy, Cameron H Good

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引用次数: 0

摘要

简介：在美国，阿片类药物使用障碍（OUD）是一个严重而持久的问题，非药物治疗方法有限，尤其是针对大多数成瘾者同时出现的睡眠障碍。虽然低强度聚焦超声（LIFU）等新型非侵入性干预措施在针对整个成瘾和康复过程中受到影响的大脑区域方面显示出了前景，但这些设备目前的形式不适合门诊治疗，也不能在夜间睡眠时使用。为了弥补这一缺陷，并为在家反复使用提供一种急需的治疗选择，我们开发了一种可穿戴的 LIFU 设备，可在门诊以外使用：本研究评估了便携式治疗设备在无人监督的居家环境中对 OUD 康复者的可行性和可接受性。研究人员从美国马里兰州巴尔的摩市的一家门诊治疗机构招募了 31 名受试者，并要求他们与另外 14 名健康对照组（HC）一起连续 7 晚佩戴纯脑电图（非 LIFU）设备原型，以评估他们是否愿意并坚持每晚使用该设备。参与者使用智能手机应用程序 TrialKit (ePRO) 自我报告每晚睡眠数据（如持续时间、质量、可能出现的干扰和设备舒适度）：在招募的 31 名 OUD 参与者中，有 30 人（97%）成功完成了居家研究，大多数人表示他们会参与未来使用头戴式可穿戴设备的研究（OUD，87%；HC，71%）。据统计，OUD 参与者比 HC 更有可能回答他们将来会考虑使用该设备帮助睡眠（OUD，70%；HC，29%）。尽管一些参与者面临技术问题（如缺乏可靠的电话接入或手机数据计划），但 OUD 组与健康对照组一样表现出较高的研究依从性：讨论：参与者的日常 ePRO 和退出访谈结果表明，对于面临 OUD 康复挑战的人群来说，在家中使用先进的治疗技术是可行的。更重要的是，许多参与者都表示非常愿意参加未来由 LIFU 支持的干预研究，以解决他们在康复期间持续存在的睡眠问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Feasibility and acceptability of wearing a neuromodulation device at night in individuals in recovery from opioid use disorder.

Introduction: Opioid use disorder (OUD) is a serious and persistent problem in the United States with limited non-pharmacological treatment options, especially for the concomitant sleep disorders experienced by most individuals with addiction. While new, non-invasive interventions such as low-intensity focused ultrasound (LIFU) have shown promise in targeting the brain regions impacted throughout addiction and recovery, the devices used are not amenable to outpatient treatment in their current form factor and cannot be used at night during sleep. To bridge this gap and provide a much-needed treatment option for repeated, at-home use, we developed a wearable LIFU device out-of-clinic use.

Methods: This study evaluated the feasibility and acceptability of the portable treatment device among individuals recovering from OUD in an unsupervised, at-home setting. 31 subjects were recruited from a Baltimore, Maryland (USA) outpatient treatment facility and, along with a separate group of 14 healthy controls (HC), were asked to wear a prototype EEG-only (non-LIFU) device for 7 consecutive nights to assess their willingness and adherence to nightly use. Participants used a smartphone application, TrialKit (ePRO), to self-report nightly sleep data (e.g. duration, quality, possible disturbances, and device comfort).

Results: Of the 31 OUD participants recruited, 30 (97%) successfully completed the at-home study, and the majority responded that they would participate in future studies using the head wearable device (OUD, 87%; HC, 71%). OUD participants were statistically more likely than HCs to respond that they would consider using the device in the future to help them sleep (OUD, 70%; HC, 29%). Despite some participants facing technological issues (e.g. lack of reliable phone access or cellular data plans), the OUD group demonstrated high study compliance on par with the healthy control group.

Discussion: Participant's daily ePRO and exit interview results established that at-home use of advanced treatment technology is feasible in a population group challenged with recovering from OUD. Even more so, numerous participants noted strong willingness to participate in future LIFU-enabled intervention studies to address their persistent sleep issues during recovery.

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来源期刊

Frontiers in Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

6.20

自引率

8.50%

发文量

2813

审稿时长

14 weeks

期刊介绍： Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.