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IF 1.9 3区医学 Q2 OTORHINOLARYNGOLOGY

European Archives of Oto-Rhino-Laryngology Pub Date : 2024-12-16 DOI:10.1007/s00405-024-09146-2

Jun Dong, Zhengqiu Zhu

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引用次数: 0

摘要

目的：本研究旨在探讨选择性颈部切除术（END）对cT3/T4N0上颌窦鳞状细胞癌（MSSCC）患者预后的影响：数据来自SEER数据库。研究纳入了cT3/T4a/T4bN0上颌窦鳞状细胞癌患者，并将其分为两组：接受END治疗组和未接受END治疗组。两组之间的差异采用倾向得分匹配法进行评估。采用Cox回归筛选患者的独立风险因素。探讨了END对癌症特异性生存（CSS）和总生存（OS）的影响，并进行了亚组分析：共有 327 名 cT3/T4N0 MSSCC 患者入组。经过倾向得分匹配（PSM）后，与未接受END治疗的患者相比，接受END治疗的患者的总生存期（OS）和癌症特异性生存期（CSS）均有显著改善（P 结论：END可改善患者的生存时间和生存质量：END可改善cT3/T4a/T4bN0 MSSCC患者的生存时间和生存结果，尤其是cT3患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prognostic analysis of elective neck dissection in cT3/T4a/T4bN0 maxillary sinus squamous cell carcinoma.

Purpose: This study aimed to examine the effect of elective neck dissection (END) on the prognosis of patients with cT3/T4N0 maxillary sinus squamous cell carcinoma (MSSCC).

Methods: Data were obtained from the SEER database. Patients with cT3/T4a/T4bN0 MSSCC were included in the study and divided into two groups: those who received END treatment and those who did not. Differences between the two groups were assessed using propensity score matching. Cox regression was used to screen patients for independent risk factors. The effect of END on cancer-specific survival (CSS) and overall survival (OS) was explored, and subgroup analyses were performed.

Results: A total of 327 patients with cT3/T4N0 MSSCC were enrolled. After propensity score matching (PSM), patients treated with END showed significant improvement in overall survival (OS) and cancer-specific survival (CSS) compared with those who did not receive END (P < 0.05). In subgroup analyses, the hazard ratio was 0.729 (95% confidence interval: 0.549-0.967), indicating a favourable prognosis for patients receiving END. Certain subgroups of patients benefited significantly from END. These subgroups included patients older than 65 years, Caucasian, male, not receiving radiotherapy, stage T3, grade II and MSSCC with a tumour size of 3-5 cm.

Conclusion: END improves survival time and survival outcomes in patients with cT3/T4a/T4bN0 MSSCC, especially in cT3 patients.

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来源期刊

European Archives of Oto-Rhino-Laryngology 医学-耳鼻喉科学

CiteScore

5.30

自引率

7.70%

发文量

537

审稿时长

2-4 weeks

期刊介绍： Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.