Minh Duc Ta, Yeongeun Kim, Hwarang Shin, Van Gia Truong, Hyun Wook Kang
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引用次数: 0
摘要
使用扩散涂抹器（DA）进行间质激光治疗（ILT）已被用于治疗肿瘤。然而，人们对 DA 发射曲线的治疗效果和安全性还缺乏深入研究。本研究调查了DA的发射曲线对前列腺肿瘤治疗的影响。使用波长为 980 nm、功率为 5 W、持续时间为 60 s 的双峰值和近端/远端峰值轮廓进行了测试，通过数值模拟和实验比较了软组织的热凝固程度。数值模拟预测了组织中的温度变化。使用体内猪肝模型和体内大鼠模型来比较剖面的性能。在体外和体内，双峰剖面产生的凝固范围几乎与平顶剖面（模拟）相当，是其他剖面的 1.3 倍。可以预见，双峰剖面会在辐照区域内产生均匀的凝固。我们将使用不同大小的肿瘤进行进一步的体内研究，以评估双峰轮廓用于前列腺肿瘤 ILT 的有效性和安全性。
Quantitative investigations on light emission profiles for interstitial laser treatment.
Interstitial laser treatment (ILT) using a diffusing applicator (DA) has been employed to treat tumors. However, the treatment efficacy and safety of the emission profiles from DAs have been poorly explored. This study investigated the effect of the emission profiles from DAs on prostate tumor treatment. Dual-peak and proximal-/distal-end peak profiles using 980 nm laser at 5 W for 60 s were tested to compare the extent of thermal coagulation in soft tissue numerically and experimentally. The numerical simulation predicted the temperature development in the tissue. Ex vivo porcine liver and in vivo rat models were used to compare the performance of the profiles. The dual-peak profile yielded a coagulation extent that was almost equivalent to that of the flat-top profile (in simulation) and 1.3 times larger than those of the other profiles in both ex vivo and in vivo. The dual-peak profile predictably entailed uniform coagulation within the irradiated region. Further in vivo studies using different tumor sizes will be evaluated to warrant the efficacy and safety of the dual-peak profile for the ILT of prostate tumors.
期刊介绍：
The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including:
Tissue optics and spectroscopy
Novel microscopies
Optical coherence tomography
Diffuse and fluorescence tomography
Photoacoustic and multimodal imaging
Molecular imaging and therapies
Nanophotonic biosensing
Optical biophysics/photobiology
Microfluidic optical devices
Vision research.
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