耳念珠菌:流行病学和抗真菌策略。

IF 15.1 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Annual review of medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI:10.1146/annurev-med-061523-021233
Emily F Eix, Jeniel E Nett
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引用次数: 0

摘要

耳念珠菌是最近出现的一种真菌病原体,在全球卫生保健机构中引起严重感染。将金黄色葡萄球菌与其他真菌病原体区分开来的一个特征是其在皮肤上定植的高能力,从而通过患者之间的传播在医疗机构中广泛暴发。金黄色念珠菌可以在皮肤或周围环境中持续很长一段时间,它比其他念珠菌表现出更强的抗真菌能力。这些因素是预防和治疗耳念珠菌感染的主要障碍。最近的报告已经确定了经常定植的皮肤部位,发展为侵袭性感染的危险因素,以及耳念珠菌菌株的抗真菌耐药性模式,所有这些都有助于指导治疗方案。在这篇综述中,我们重点介绍了金黄色葡萄球菌流行病学和抗真菌耐药性的关键研究,讨论了这些因素如何影响医疗相关的传播和治疗结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Candida auris: Epidemiology and Antifungal Strategy.

Candida auris is a recently emerged fungal pathogen that causes severe infections in healthcare settings around the globe. A feature that distinguishes C. auris from other fungal pathogens is its high capacity to colonize skin, leading to widespread outbreaks in healthcare facilities via patient-to-patient transmission. C. auris can persist on skin or in the surrounding environment for extended periods of time, and it exhibits greater antifungal resistance than other Candida species. These factors pose major obstacles for the prevention and treatment of C. auris infection. Recent reports have identified frequently colonized skin sites, risk factors for developing invasive infection, and patterns of antifungal resistance among C. auris strains, all of which help guide therapeutic options. In this review, we highlight key studies of C. auris epidemiology and antifungal resistance, discussing how these factors influence healthcare-associated transmission and treatment outcomes.

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来源期刊
Annual review of medicine
Annual review of medicine 医学-医学:内科
CiteScore
24.90
自引率
0.00%
发文量
58
期刊介绍: The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.
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