QOL-B-RD和PROMIS-F SF-7a的内容验证，用于测量澳门巴黎人娱乐官网肺病的呼吸道症状和疲劳症状。

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in Therapy Pub Date : 2024-12-16 DOI:10.1007/s12325-024-03064-9

Kelly P. McCarrier, Mariam Hassan, Dayton W. Yuen, Jui-Hua Tsai, Nancy Touba, Kevin C. Mange

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引用次数: 0

摘要

生活质量-支气管扩张（QOL-B）问卷和患者报告的结果测量信息系统短格式v1.0-疲劳7a （promisf - SF-7a）有可能分别测量鸟分枝杆菌（MAC）肺部疾病患者的呼吸和疲劳症状，但尚未对该人群的内容效度进行评估。方法：对美国目前确诊为MAC肺病的患者进行半结构化定性访谈。进行概念启发（CE）访谈（n = 25名参与者），以确定对MAC肺病患者重要且相关的关键呼吸和疲劳症状，并评估QOL-B和promisi - f SF-7a测量这些症状的适用性。随后进行认知访谈（ci）（n = 20名参与者），以评估QOL-B呼吸域（QOL-B- rd）和promise - f SF-7a的相关性、可理解性和适当性。所有访谈都被记录、转录和编码，以进行定性内容分析。结果：CE访谈参与者最重要或相关的呼吸症状概念是“咳嗽”、“活动时呼吸短促”和“粘液/痰”。最重要或相关的疲劳症状概念是“疲劳”、“缺乏能量”和“容易疲劳/耐力低”。QOL-B-RD和promise - f SF-7a中的现有项目涵盖了这些症状。认知访谈参与者的反馈证实了每个工具的项目内容、回答选项、概念属性和回忆期对大多数MAC肺病患者是有效的、相关的和有意义的。基于第1波的发现，QOL-B指南在第2波访谈中被修改，其中引用“支气管扩张”的文本被替换为“您的肺部状况”。第二阶段参与者的反馈确认了修改后的指导措辞是容易理解和适当的。结论：本研究结果支持QOL-B-RD和promisi - f SF-7a的内容效度，它们分别被证明与评估MAC肺病患者的呼吸和疲劳症状相关且合适。

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Content Validation of the QOL-B-RD and PROMIS-F SF-7a to Measure Respiratory and Fatigue Symptoms of MAC Lung Disease

Introduction

The Quality of Life-Bronchiectasis (QOL-B) questionnaire and Patient Reported Outcome Measurement Information System Short Form v1.0—Fatigue 7a (PROMIS-F SF-7a) have the potential to measure respiratory and fatigue symptoms, respectively, in patients with Mycobacterium avium complex (MAC) lung disease but have not yet been evaluated for content validity in this population.

Methods

Semi-structured qualitative interviews were conducted in United States patients with a current MAC lung disease diagnosis. Concept elicitation (CE) interviews were conducted (n = 25 participants) to identify key respiratory and fatigue symptoms expressed as important and relevant to patients with MAC lung disease and to evaluate the appropriateness of the QOL-B and PROMIS-F SF-7a to measure these symptoms. Cognitive interviews (CIs) were subsequently conducted (n = 20 participants) to evaluate the relevance, comprehensibility, and appropriateness of the QOL-B respiratory domain (QOL-B-RD) and PROMIS-F SF-7a. All interviews were recorded, transcribed, and coded for qualitative content analysis.

Results

The most important or relevant respiratory symptom concepts to CE interview participants were “cough,” “shortness of breath during activity,” and “mucus/phlegm.” The most important or relevant fatigue symptom concepts were “tiredness,” “lack of energy,” and “tire easily/low stamina.” These symptoms are covered by existing items in the QOL-B-RD and PROMIS-F SF-7a. Cognitive interview participants’ feedback confirmed the item content, response options, concept attributes, and recall period for each instrument were effective, relevant, and meaningful to most patients with MAC lung disease. Based on Wave 1 findings, the QOL-B instructions were revised for the Wave 2 interviews, where the text referencing “bronchiectasis” was replaced with “your lung condition.” Participant feedback in Wave 2 confirmed the revised instruction wording was easily understood and appropriate.

Conclusions

The study results support the content validity of the QOL-B-RD and PROMIS-F SF-7a, which were shown to be relevant and appropriate to evaluate respiratory and fatigue symptoms, respectively, in patients with MAC lung disease.

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来源期刊

Advances in Therapy 医学-药学

CiteScore

7.20

自引率

2.60%

发文量

353

审稿时长

6-12 weeks

期刊介绍： Advances in Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Advances in Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.