血镉和体力活动与死亡率的关系:前瞻性队列研究

IF 6.2 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Yilin Chen , Cien Zhen , Lin Zeng , Hongliang Feng , Jinyu Wang , Qi Yong H. Ai , Sizhi Ai , Jihui Zhang , Yannis Yan Liang , Huachen Xue , Yujing Zhou
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引用次数: 0

摘要

体力活动(PA)可以被认为是一种替代方法,以改善与镉暴露相关的高死亡率风险。在这项前瞻性队列研究中,从2007年至2018年的全国健康与营养检查调查中选择了总共20253名参与者(加权平均年龄47.79岁),其中包括10247名18岁及以上的男性(加权患病率:50.1% %)。使用多变量Cox比例风险回归模型来评估血镉水平、PA和死亡风险之间的关系。采用限制三次样条分析探讨血镉和PA水平与死亡风险之间的非线性关系。在7.6年的中位随访期间,总共发生了2002例(9.89 %)全因死亡,其中581例(2.87 %)参与者死于心血管疾病(CVD), 498例(2.46 %)参与者死于癌症。血镉与死亡风险呈j形相关(均< 0.001;所有非线性均< 0.001)。血镉与PA对死亡风险呈乘法互作(p互作均< 0.05)。与血镉含量最低四分位数和推荐PA的亚组相比,血镉含量最高四分位数和不推荐PA的组合与全因死亡和癌症死亡的风险最高相关,其次是达到推荐PA但血镉含量最高四分位数的亚组(风险比,2.43;95 %置信区间,1.95-3.02)。达到推荐的PA水平显著降低了血镉对全因、心血管疾病和癌症死亡风险的有害影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of blood cadmium and physical activity with mortality: A prospective cohort study
Physical activity (PA) may be considered an alternative method to ameliorate the elevated mortality risks associated with cadmium exposure. In this prospective cohort study, a total of 20,253 participants (weighted mean age, 47.79 years), including 10,247 men (weighted prevalence: 50.1 %), aged 18 years or older, were selected from the National Health and Nutrition Examination Survey from 2007 to 2018. Multivariable Cox proportional hazards regression models were utilized to evaluate the associations between blood cadmium levels, PA, and the risks of mortality. Restricted cubic spline analyses were employed to investigate the nonlinear relationships between blood cadmium and PA levels and mortality risks. During a median follow-up of 7.6 years, a total of 2002 (9.89 %) all-cause deaths occurred, of which 581 (2.87 %) participants were due to cardiovascular disease (CVD) and 498 (2.46 %) died of cancer. J-shaped associations were observed for blood cadmium with risks of mortality (all P overall < 0.001; all P nonlinearity < 0.001). Blood cadmium and PA had multiplicative interactions on mortality risk (all P interaction < 0.05). Compared with the subgroup with the lowest quartile of blood cadmium and recommended PA, the combination of the highest quartile of blood cadmium and without recommended PA was associated with the highest risks of all-cause and cancer mortality, followed by those meeting recommended PA but in the highest quartile of blood cadmium (hazard ratios, 2.43; 95 % confidence interval, 1.95–3.02). Achieving recommended PA significantly attenuated the detrimental effects of blood cadmium on all-cause, CVD, and cancer mortality risks.
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来源期刊
CiteScore
12.10
自引率
5.90%
发文量
1234
审稿时长
88 days
期刊介绍: Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.
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