{"title":"Ascorbate/methionine-based CH<sub>4</sub> delivery nanomedicine for tumor-targeted therapy.","authors":"Xiaoyu Li, Chao Xia, Zhaokui Jin, Qianjun He","doi":"10.1016/j.biomaterials.2024.123002","DOIUrl":null,"url":null,"abstract":"<p><p>Methane (CH<sub>4</sub>) is identified to be an emerging anti-inflammation and anti-cancer molecule with high bio-safety, but the targeted delivery of CH<sub>4</sub> is a thorny challenge. Herein, we propose a CH<sub>4</sub> delivery strategy based on an intratumoral H<sub>2</sub>O<sub>2</sub>-triggered cascade reaction of ascorbic acid (AA)/methionine (Met), and have constructed a new nanomedicine (AMN) for tumor-targeted CH<sub>4</sub> therapy. Encouragingly, AMN realizes the effective tumor-targeted delivery and intratumoral H<sub>2</sub>O<sub>2</sub>-responsive release of CH<sub>4</sub>, and exhibits significant anti-cancer effects and high bio-safety. Mechanistically, we have discovered that intratumoral released CH<sub>4</sub> can not only induce the apoptosis of 4T1 tumor cells by inhibiting their mitochondrial metabolism, but also activate tumor immunotherapy by reprogramming tumor-associated macrophages (TAMs) phenotype (M2 to M1). The combination of the above anti-cancer pathways by virtue of tumor-targeted CH<sub>4</sub> delivery makes contribution to outstanding anti-cancer efficacy of AMN. The proposed CH<sub>4</sub> delivery strategy opens a new window for safe and effective tumor therapy.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123002"},"PeriodicalIF":12.8000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.biomaterials.2024.123002","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/10 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Ascorbate/methionine-based CH4 delivery nanomedicine for tumor-targeted therapy.
Methane (CH4) is identified to be an emerging anti-inflammation and anti-cancer molecule with high bio-safety, but the targeted delivery of CH4 is a thorny challenge. Herein, we propose a CH4 delivery strategy based on an intratumoral H2O2-triggered cascade reaction of ascorbic acid (AA)/methionine (Met), and have constructed a new nanomedicine (AMN) for tumor-targeted CH4 therapy. Encouragingly, AMN realizes the effective tumor-targeted delivery and intratumoral H2O2-responsive release of CH4, and exhibits significant anti-cancer effects and high bio-safety. Mechanistically, we have discovered that intratumoral released CH4 can not only induce the apoptosis of 4T1 tumor cells by inhibiting their mitochondrial metabolism, but also activate tumor immunotherapy by reprogramming tumor-associated macrophages (TAMs) phenotype (M2 to M1). The combination of the above anti-cancer pathways by virtue of tumor-targeted CH4 delivery makes contribution to outstanding anti-cancer efficacy of AMN. The proposed CH4 delivery strategy opens a new window for safe and effective tumor therapy.
期刊介绍：
Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.
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