抗肿瘤坏死因子治疗期间降痛调节的变化。类风湿关节炎和脊椎关节炎的前瞻性研究

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2024-12-16 DOI:10.1002/art.43084

Anne-Priscille Trouvin, Arielle Simunek, Joël Coste, Terkia Medkour, Alice Combier, Lucile Poiroux, François Vidal, Sandrine Carvès, Didier Bouhassira, Serge Perrot

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引用次数: 0

摘要

在类风湿性关节炎（RA）和脊椎关节炎（SpA）中，管理持续性疼痛仍然具有挑战性。关于这些患者的疼痛通路受损和bDMARDs的影响，我们知之甚少。RAPID（风湿病疼痛抑制下降途径）研究的目的是评估活动性RA或SpA患者在引入TNF抑制剂后的疼痛阈值和下降疼痛调节。(TNFi)

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Changes in descending pain modulation during anti-TNF therapy. A prospective study in rheumatoid arthritis and spondyloarthritis

In rheumatoid arthritis (RA) and spondyloarthritis (SpA), managing persistent pain remains challenging. Little is known regarding impaired pain pathways in these patients and the impact of bDMARDs. The objective of the RAPID (Rheumatism Pain Inhibitory Descending pathways) study was to assess pain thresholds and descending pain modulation in patients with active RA or SpA following introduction of a TNF inhibitor. (TNFi)

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.