IF 7.7 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Jiao Wang, Na Li, Cheng Kun Xiao, Shu Shu Han, Min Jie Lu, Xiao Yi Lin, Ze Fang Ren, Lin Xu
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引用次数: 0

摘要

广州乳腺癌研究(GBCS)是一项以患者为基础的前瞻性队列研究,旨在确定乳腺癌(BC)发病和预后的风险因素和潜在机制,特别是解决华南地区乳腺癌发病率明显偏高的个体化预防需求。GBCS以中国广州为基地,于2008年开始招募研究人员,包括三项互补研究:由5471名乳腺癌患者组成的广州乳腺癌队列、由1551名病例和1605名对照者组成的病例对照研究,以及由1063名乳腺癌患者组成的免疫组化(IHC)队列。参与者的年龄主要在 41-60 岁之间。队列随访第一年每三个月进行一次,第二年和第三年每六个月进行一次,之后每年进行一次。直到 2023 年,广州乳腺癌队列中仍有 73.5%、IHC 队列中仍有 98.6%的患者在接受随访,随访率很高。基线数据收集包括人口学特征和乳腺癌风险因素,随访数据包括生存率、治疗细节、疾病史、职业史、诊断后生活方式以及实验室测量,包括遗传标记、蛋白质和环境暴露。该研究鼓励全球合作,如有具体研究想法或建议,请联系通讯作者:xulin27@ mail.sysu.edu.cn。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cohort profile: Guangzhou breast cancer study (GBCS)

The Guangzhou Breast Cancer Study (GBCS) is a patient-based prospective cohort study designed to identify risk factors and underlying mechanisms for breast cancer (BC) incidence and prognosis, specifically addressing the need for individualized prevention in South China, where BC incidence is notably high. Based in Guangzhou, China, the GBCS began recruitment in 2008, comprises three complementary studies: the Guangzhou breast cancer cohort with 5471 breast cancer patients, a case–control study with 1551 cases and 1605 controls, and an immunohistochemistry (IHC) cohort with 1063 breast cancer patients. Participants are primarily aged 41–60 years. Cohort follow-up is conducted every three months in the first year, every six months in the second and third years, and annually thereafter. High follow-up rates have been achieved until 2023, with 73.5% for the Guangzhou breast cancer cohort and 98.6% for the IHC cohort still active. Baseline data collection included demographic characteristics and breast cancer risk factors, while follow-up data included survival, treatment details, disease history, occupational history, post-diagnostic lifestyle, and laboratory measures, including genetic markers, proteins, and environmental exposures. The study encourages global collaborations and invites interested researchers to contact the corresponding author at xulin27@ mail.sysu.edu.cn with specific research ideas or proposals.

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来源期刊
European Journal of Epidemiology
European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
21.40
自引率
1.50%
发文量
109
审稿时长
6-12 weeks
期刊介绍: The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.
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