小脑对情绪调节的贡献及其与内侧额叶GABA水平的关系

Yumi Oboshi, Toshiki Iwabuchi, Yohei Takata, Tomoyasu Bunai, Yasuomi Ouchi
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引用次数: 0

摘要

拉开距离是指改变视角,改变与引起情绪反应的刺激物的心理距离,以此来调节情绪。本研究采用磁共振波谱(MRS)和功能磁共振成像技术,旨在研究:1)通过拉开距离进行情绪上调的神经相关因素在不同情绪价位(即对积极和消极图片的情绪反应)下是否存在差异;2)情绪调节的关键区域之一--内侧前额叶皮层(MPFC)中的γ-氨基丁酸(GABA)浓度与消极或积极情绪上调相关的大脑活动是否存在关联。34 名健康的日本成年人参加了这项研究。与积极情绪上调的条件相比,消极情绪上调引起了MPFC、左侧颞顶叶交界处、双侧前岛叶、前辅助运动区和双侧小脑的激活增加。相反,在比较积极情绪上调和消极情绪上调时,没有发现明显的激活现象。负性情绪上调时的右侧小脑活动与大脑中枢皮层的GABA浓度呈正相关。这些发现为小脑通过疏远参与负面情绪上调及其与前额叶GABA浓度的关联提供了证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebellar contribution to emotion regulation and its association with medial frontal GABA level.

Distancing involves changing perspectives to alter the psychological distance from stimuli that elicit emotional reactions as a tactic to regulate emotions. Using magnetic resonance spectroscopy (MRS) and functional magnetic resonance imaging, this study aimed to examine 1) whether the neural correlates of emotion upregulation via distancing differ across emotional valence (i.e., emotional responses toward positive and negative pictures), and 2) whether the gamma-aminobutyric acid (GABA) concentration in the medial prefrontal cortex (MPFC), one of the crucial areas of emotion regulation, is correlated with brain activity related to either negative or positive emotion upregulation. Thirty-four healthy Japanese adults participated in this study. Compared to the condition involving positive emotion upregulation, negative emotion upregulation induced increased activation in the MPFC, left temporoparietal junction, bilateral anterior insula, pre-supplementary motor area, and bilateral cerebellum. In contrast, when comparing positive emotion upregulation with negative emotion upregulation, no significant activation was found. Right cerebellar activity during negative emotion upregulation positively correlated with GABA concentration in the MPFC. These findings provide evidence of cerebellar involvement in the upregulation of negative emotion via distancing and its association with the prefrontal GABA concentration.

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