胶质瘤中的 TERT 启动子突变:在肿瘤发生、转移、诊断、预后、靶向治疗和耐药性中的分子作用。

Avaniyapuram Kannan Murugan, Siddarth Kannan, Ali S Alzahrani
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引用次数: 0

摘要

端粒酶逆转录酶(TERT)是细胞永生化过程中的关键角色,由于其启动子在各种人类恶性肿瘤中频繁发生突变,它已成为研究的焦点。TERT 启动子突变在肿瘤发生中起着重要作用,可促进细胞肆意增殖和存活。这篇全面的综述深入探讨了 TERT 启动子突变的情况及其在癌症(尤其是胶质瘤)中的深远影响。本文细致研究了TERT启动子突变与转移级联之间错综复杂的相互作用,揭示了它们在胶质瘤中协调侵袭行为的能力。此外,这篇综述还描述了以TERT为靶点的最新治疗趋势,并剖析了与TERT突变相关的耐药性的演变情况,为潜在的治疗挑战提供了见解。此外,还仔细研究了胶质瘤中 TERT 启动子突变对诊断和预后的影响,揭示了其作为强大生物标志物的潜力。本综述还讨论了分子诊断的最新进展,展示了 TERT 基因突变作为诊断工具和预后指标的前景。本综述旨在加深对胶质瘤中 TERT 启动子突变的理解,为未来的研究工作奠定基础,并为胶质瘤管理的创新策略铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
TERT promoter mutations in gliomas: Molecular roles in tumorigenesis, metastasis, diagnosis, prognosis, therapeutic targeting, and drug resistance.

Telomerase reverse transcriptase (TERT), a critical player in cellular immortalization, has emerged as a focal point of investigation due to its frequent promoter mutations in various human malignancies. TERT promoter mutations exhibit a significant role in tumorigenesis, fostering unbridled cellular proliferation and survival. This comprehensive review delves into the landscape of TERT promoter mutations and their profound implications in cancer, particularly within the context of gliomas. This article meticulously examines the intricate interplay between TERT promoter mutations and the metastatic cascade, shedding light on their capacity to orchestrate invasive behavior in gliomas. Moreover, this review describes the recent trends in therapeutic targeting of the TERT and dissects the evolving landscape of drug resistance associated with TERT mutations, providing insights into potential therapeutic challenges. In addition, the diagnostic and prognostic implications of TERT promoter mutations in gliomas are scrutinized, unraveling their potential as robust biomarkers. It also discusses the recent advancements in molecular diagnostics, illustrating the promise of TERT mutations as diagnostic tools and prognostic indicators. This review collectively aims to contribute to a deeper understanding of TERT promoter mutations in gliomas, offering a foundation for future research endeavors and paving the way for innovative strategies in glioma management.

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