绝经对纤维肌痛妇女和健康妇女循环氨基酸浓度的影响。

IF 3.9 2区医学 Q2 GERIATRICS & GERONTOLOGY

Maturitas Pub Date : 2025-02-01 DOI:10.1016/j.maturitas.2024.108171

Alma Rus , Bárbara Coca-Guzmán , Francisco Molina , María Correa-Rodríguez , José Manuel Martínez-Martos , María Jesús Ramírez-Expósito , María Encarnación Aguilar-Ferrándiz

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引用次数: 0

摘要

目的：纤维肌痛是一种复杂的综合征，更频繁地出现在更年期。以前没有研究调查过绝经对纤维肌痛妇女体内氨基酸的影响。因此，我们检测了绝经前和绝经后纤维肌痛妇女和健康妇女的血清氨基酸浓度。研究设计：对28名绝经前和46名绝经后健康妇女以及16名绝经前和52名绝经后纤维肌痛妇女进行病例对照研究。本研究遵循STROBE指南。主要观察指标：高效液相色谱法测定氨基酸含量。结果：在健康的绝经前妇女和绝经前纤维肌痛妇女之间以及健康的绝经后妇女和绝经后纤维肌痛妇女之间，发现了几种氨基酸（天冬氨酸、谷氨酸、组氨酸、甘氨酸、丙氨酸、亮氨酸和牛磺酸）浓度的显著差异。其他氨基酸（氨基己二酸、天冬氨酸、苏氨酸、精氨酸、5-甲基组氨酸、缬氨酸、蛋氨酸、异亮氨酸、苯丙氨酸、鸟氨酸、支链氨基酸、大中性氨基酸、必需氨基酸、非必需氨基酸、碱性氨基酸和精氨酸/鸟氨酸比率）的浓度在健康绝经后妇女和患有纤维肌痛的绝经后妇女之间存在差异。但在健康的绝经前妇女和患有纤维肌痛的绝经前妇女之间没有。绝经前和绝经后健康妇女，绝经前和绝经后纤维肌痛妇女之间血清氨基酸浓度无显著差异。结论：我们的研究结果首次表明，绝经和纤维肌痛之间的关联可能比绝经或纤维肌痛单独存在更大程度上破坏氨基酸稳态，从而增加代谢紊乱的风险。

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Effect of menopause on circulating amino acid concentrations in women with fibromyalgia and healthy women

Objectives

Fibromyalgia is a complex syndrome that appears more frequently during menopause. No previous studies have investigated the effect of menopause on amino acids in women with fibromyalgia. Therefore, we have examined serum amino acid concentrations in premenopausal and postmenopausal women with fibromyalgia and healthy women.

Study design

A case-control study was carried out in 28 premenopausal and 46 postmenopausal healthy women and in 16 premenopausal and 52 postmenopausal women with fibromyalgia. This study adheres to STROBE guidelines.

Main outcome measures

Amino acid content was assayed using high-performance liquid chromatography.

Results

Significant differences were found in concentrations of several amino acids (aspartic acid, glutamic acid, histidine, glycine, alanine, leucine, and taurine) between healthy premenopausal women and premenopausal women with fibromyalgia and between healthy postmenopausal women and postmenopausal women with fibromyalgia. Concentrations of other amino acids (aminoadipic acid, asparagine, threonine, arginine, 5-methyl-histidine, valine, methionine, isoleucine, phenylalanine, ornithine, branched-chain amino acids, large neutral amino acids, essential amino acids, non-essential amino acids, basic amino acids, and arginine/ornithine ratio) were found to differ between healthy postmenopausal women and postmenopausal women with fibromyalgia, but not between healthy premenopausal women and premenopausal women with fibromyalgia. No significant differences were found in serum amino acid concentrations between premenopausal and postmenopausal healthy women or between premenopausal and postmenopausal women with fibromyalgia.

Conclusions

Our results show, for the first time, that the association between menopause and fibromyalgia may increase the risk of metabolic disorders by disrupting amino acid homeostasis to a greater extent than menopause or fibromyalgia alone.

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来源期刊

Maturitas 医学-妇产科学

CiteScore

9.10

自引率

2.00%

发文量

142

审稿时长

40 days

期刊介绍： Maturitas is an international multidisciplinary peer reviewed scientific journal of midlife health and beyond publishing original research, reviews, consensus statements and guidelines, and mini-reviews. The journal provides a forum for all aspects of postreproductive health in both genders ranging from basic science to health and social care. Topic areas include:• Aging• Alternative and Complementary medicines• Arthritis and Bone Health• Cancer• Cardiovascular Health• Cognitive and Physical Functioning• Epidemiology, health and social care• Gynecology/ Reproductive Endocrinology• Nutrition/ Obesity Diabetes/ Metabolic Syndrome• Menopause, Ovarian Aging• Mental Health• Pharmacology• Sexuality• Quality of Life