Intraoperative Real-Time IDH Diagnosis for Glioma Based on Automatic Analysis of Contrast-Enhanced Ultrasound Video

Objective

Isocitrate dehydrogenase (IDH) is the most important molecular marker of glioma and is highly correlated to the diagnosis, treatment, and prognosis of patients. We proposed a real-time diagnosis method for IDH status differentiation based on automatic analysis of intraoperative contrast-enhanced ultrasound (CEUS) video.

Methods

Inspired by the Time Intensity Curve (TIC) analysis of CEUS utilized in clinical practice, this paper proposed an automatic CEUS video analysis method called ATAN (Automatic TIC Analysis Network). Based on tumor identification, ATAN automatically selected ROIs (region of interest) inside and outside glioma. ATAN ensures the integrity of dynamic features of perfusion changes at critical locations, resulting in optimal diagnostic performance. The transfer learning mechanism was also introduced by using two auxiliary CEUS datasets to solve the small sample problem of intraoperative glioma data.

Results

Through pretraining on 258 patients on two auxiliary cohorts, ATAN produced the IDH diagnosis with accuracy and AUC of 0.9 and 0.91 respectively on the main cohort of 60 glioma patients (mean age, 50 years ± 14, 28 men) Compared with other existing IDH status differentiation methods, ATAN is a real-time IDH diagnosis method without the need of tumor samples.

Conclusion

ATAN is an effective automatic analysis model of CEUS, with the help of this model, real-time intraoperative diagnosis of IDH with high accuracy can be achieved. Compared with other state-of-the-art deep learning methods, the accuracy of the ATAN model is 15% higher on average.