Dengue virus importation risks in Africa: a modelling study

Background

Dengue is a significant global public health concern that poses a threat in Africa. Particularly, African countries are at risk of viral introductions through air travel connectivity with areas of South America and Asia in which explosive dengue outbreaks frequently occur. Limited reporting and diagnostic capacity hinder a comprehensive assessment of continent-wide transmission dynamics and deployment of surveillance strategies in Africa. In this study, we aimed to identify African airports at high risk of receiving passengers with dengue from Asia, Latin America, and other African countries with high dengue incidence.

Methods

For this modelling study, air travel flow data were obtained from the International Air Transport Association database for 2019. Data comprised monthly passenger volumes from 14 high-incidence countries outside of Africa and 18 countries within the African continent that reported dengue outbreaks in the past 10 years to 54 African countries, encompassing all 197 commercial airports in both the source and destination regions. The risk of dengue introduction into Africa from countries of high incidence in Asia, Latin America, and within Africa was estimated based on origin–destination air travel flows and epidemic activity at origin. We produced a novel proxy for local dengue epidemic activity using a composite index of theoretical climate-driven transmission suitability and population density, which we used, in addition to travel information in a risk flow model, to estimate importation risk.

Findings

Countries in eastern Africa had a high estimated risk of dengue importation from Asia and other east African countries, whereas for west African countries, the risk of importation was higher from within the region than from countries outside of Africa. Some countries with high risk of importation had low local transmission suitability, which is likely to hamper the risk that dengue importations would lead to local transmission and establishment of a dengue outbreak. Mauritius, Uganda, Côte d'Ivoire, Senegal, and Kenya were identified as countries susceptible to dengue introductions during periods of persistent transmission suitability.

Interpretation

Our study improves data-driven allocation of surveillance resources, in regions of Africa that are at high risk of dengue introduction and establishment, including from regional circulation. Improvements in resource allocation will be crucial in detecting and managing imported cases and could improve local responses to dengue outbreaks.

Funding

Rockefeller Foundation, National Institute of Health, EDCTP3 and Horizon Europe Research and Innovation, World Bank Group, Medical Research Foundation, Wellcome Trust, Google, Oxford Martin School Pandemic Genomics programme, and John Fell Fund.