原发性肿瘤和转移瘤中成纤维细胞的功能异质性。

IF 14.3 1区 医学 Q1 ONCOLOGY
Priscilla S W Cheng, Marta Zaccaria, Giulia Biffi
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引用次数: 0

摘要

癌症相关成纤维细胞(CAFs)是大多数实体恶性肿瘤的肿瘤微环境(TME)中的丰富成分,已成为癌症进展和治疗反应的关键调节因子。尽管最近的技术进步在单细胞水平上发现了大量的 CAF 分子异质性,但确定大多数已描述的 CAF 群体的功能作用仍具有挑战性。为了在 CAF 分子和功能异质性之间架起一座桥梁,本综述将重点关注最近发现的 CAF 亚型与原发性肿瘤和转移瘤中恶性细胞、免疫细胞和其他基质细胞之间的功能性相互作用。剖析特定 CAF 群体与其他成分的异质性功能串扰,将开始发现针对 TME 和癌症进展的候选组合治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional heterogeneity of fibroblasts in primary tumors and metastases.

Cancer-associated fibroblasts (CAFs) are abundant components of the tumor microenvironment (TME) of most solid malignancies and have emerged as key regulators of cancer progression and therapy response. Although recent technological advances have uncovered substantial CAF molecular heterogeneity at the single-cell level, defining functional roles for most described CAF populations remains challenging. With the aim of bridging CAF molecular and functional heterogeneity, this review focuses on recently identified functional interactions of CAF subtypes with malignant cells, immune cells, and other stromal cells in primary tumors and metastases. Dissecting the heterogeneous functional crosstalk of specific CAF populations with other components is starting to uncover candidate combinatorial strategies for therapeutically targeting the TME and cancer progression.

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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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