巴西 Bothrops-Lachesis-Crotalus 抗蛇毒血清中和 Crotalus durissus ruruima 响尾蛇毒液某些生物活性的能力。

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2024-12-17 DOI:10.1016/j.toxicon.2024.108211

Emiro G Muniz, Ida S Sano-Martins, Maria das Graças G Saraiva, Evela S Magno, Sâmella S Oliveira

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引用次数: 0

摘要

我们评估了冻干的Bothrops-Lachesis-Crotalus抗蛇毒血清和液体Crotalus抗蛇毒血清中和Crotalus durissus ruruima (Cdr)毒液（巴西罗赖马）与C.两种毒液的致死活性和磷脂酶 A2 活性相似，克罗他敏呈阴性，个别 Cdr 毒液会诱发小鼠出血。它的凝血作用比 Cdt 毒液低。只有Bothrops-Lachesis-Crotalus抗蛇毒血清能中和所有评估的生物活性，这表明它可用于该地区的蛇咬伤。

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Ability of brazilian Bothrops-Lachesis-Crotalus antivenom in neutralizing some biological activities of Crotalus durissus ruruima rattlesnake venom.

We evaluated the efficacy of freeze-dried Bothrops-Lachesis-Crotalus antivenom and liquid Crotalus antivenoms to neutralize Crotalus durissus ruruima (Cdr) venom (Roraima, Brazil) comparing with C. d. terrificus (Cdt) venom. Lethal and phospholipase A₂ activities were similar between both spp. Crotamine was negative and individual Cdr venoms induced hemorrhage in mice. It was lower coagulant than Cdt venom. Only Bothrops-Lachesis-Crotalus antivenom neutralized all biological activities evaluated, suggesting that it could be used in snakebites in this region.

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

期刊介绍： Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.