术后血清CEA预测hr阳性/ her2阴性早期乳腺癌的预后。

IF 2.9 3区医学 Q2 ONCOLOGY

Expert Review of Anticancer Therapy Pub Date : 2024-12-01 Epub Date: 2024-12-19 DOI:10.1080/14737140.2024.2443009

Gozde Kavgaci, Taha Koray Sahin, Tugcenur Muderrisoglu, Serez Ileri, Deniz Can Guven, Sercan Aksoy

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引用次数: 0

摘要

背景：术前癌胚抗原（CEA）在乳腺癌预后中的作用已得到认可，但术后CEA水平对早期乳腺癌患者生存的影响尚不确定。研究设计和方法：我们对921例匿名治疗的非转移性乳腺癌患者进行了回顾性研究。将患者分为正常组（CEA≤3µg/L）和升高组（CEA≤3µg/L）。结果：术后CEA水平升高与较短的无病生存期（DFS）相关(中位数，174.6个月vs 239.8个月；风险比（HR）： 1.80；95%置信区间（CI）： 1.27-2.56；p p p = 0.043)和OS (NR vs. NR；人力资源:2.81;95% ci: 1.06-7.48；p = 0.039)，较短的DFS(中位数，239。8个月vs 141.1个月；人力资源:1.95;95% ci: 1.28-2.98；p = 0.002)和OS(中位数，169 vs. 261.1个月；人力资源:2.56;95% ci: 1.6-4.12；P = 0.021)。结论：术后CEA升高表明hr阳性/ her2阴性早期乳腺癌患者的DFS和OS更差。

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Post-operative serum CEA predicts prognosis in HR-positive/HER2-negative early breast cancer.

Background: The prognostic role of preoperative carcinoembryonic antigen (CEA) in breast cancer is recognized, but the impact of postoperative CEA levels on survival in early breast cancer is uncertain.

Research design and methods: We conducted a retrospective study of 921 non-metastatic breast cancer patients treated at anonymized. Patients were categorized as normal (CEA ≤3 µg/L) or elevated (CEA >3 µg/L).

Results: Elevated postoperative CEA levels were associated with shorter disease-free survival (DFS) (median, 174.6 vs. 239.8 months; hazard ratio (HR): 1.80; 95% confidence interval (CI): 1.27-2.56; p < 0.001) and overall survival (OS) (median, 174.6 vs. 261.1 months; HR:2.34; 95% CI: 1.59-3.45; p < 0.001). Elevated CEA was associated with shorter DFS (median, 174.6 months vs. not reached (NR); HR:2.30; 95% CI: 1.03-5.19; p = 0.043) and OS (NR vs. NR; HR: 2.81; 95% CI: 1.06-7.48; p = 0.039) in stage 1, shorter DFS (median, 239. 8 vs. 141.1 months; HR: 1.95; 95% CI: 1.28-2.98; p = 0.002) and OS (median, 169 vs. 261.1 months; HR: 2.56; 95% CI: 1.6-4.12; p < 0.001) in stage 2 and shorter OS (median, 65 vs. 183.1 months; HR: 3.25; 95% CI: 1.19-8.83; p = 0.021) in stage 3.

Conclusions: Elevated postoperative CEA indicates worse DFS and OS in patients with HR-positive/HER2-negative early breast cancer.

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.