特定孕期尿铝浓度对胎儿出生时生长和体型超声测量的影响:中国妇女纵向队列研究。

IF 6.2 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ecotoxicology and Environmental Safety Pub Date : 2025-01-15 Epub Date: 2024-12-13 DOI:10.1016/j.ecoenv.2024.117509
Haiying Chen, Wenjing Yan, Xueyan Wu, Yuanyuan Li
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引用次数: 0

摘要

目的:铝(Al)被认为是影响胎儿生长的潜在因素。然而,现有的研究结果不一致,缺乏基于人群的流行病学研究。我们的研究旨在评估铝暴露与胎儿发育特征的孕期特异性相关性。方法:2013年至2016年,来自中国武汉的3599名女性被纳入前瞻性队列研究。采用电感耦合等离子体质谱法测定了妊娠1、2、3个月孕妇尿液中Al的浓度。本研究采用线性回归和广义估计方程来确定各孕期重力调整尿铝浓度与胎儿生长参数和出生尺寸指标之间的关系。结果:发现妊娠期特异性铝暴露对胎儿生长和出生参数有负面影响。妊娠早期16周双顶叶直径(BPD) (Pinteraction = 0.007)、头围(Pinteraction = 0.026)、妊娠中期24周BPD (Pinteraction = 0.015)、妊娠中期31周BPD (Pinteraction = 0.014)、妊娠晚期37周BPD (Pinteraction = 0.035)与胎儿性别的交互作用有统计学意义。Al暴露水平与BPD之间的相关性在女性胎儿中明显强于男性胎儿。此外,我们观察到三个不同的轨迹妊娠期特异性铝浓度。与Al浓度轨迹低稳定组相比,高稳定组胎儿生长参数和出生尺寸指标下降幅度更大。结论:我们的研究结果表明,Al可能对胎儿生长和出生尺寸指标有有害影响,特别是对女性胎儿。需要进一步的研究来检验我们在其他人群中的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women.

Objective: Aluminum (Al) has been proposed as a potential factor influencing fetal growth. However, the existing study findings are inconsistent and there is a lack of population-based epidemiological studies. Our study aimed to evaluate the trimester-specific correlations of Al exposure with fetal development characteristics.

Methods: Between 2013 and 2016, 3599 women from Wuhan, China were enrolled in the prospective cohort study. The concentrations of Al were quantified in urine samples obtained from pregnant women during the 1st, 2nd and 3rd trimesters by inductively coupled plasma mass spectrometry. The study used linear regressions with generalized estimating equation to determine the connections between specific gravity-adjusted urinary Al concentrations in each trimester and fetal growth parameters and birth size indicators.

Results: Trimester-specific Al exposure throughout pregnancy was found to have a negative impact on fetal growth and birth parameters. Besides, statistically significant interactions were detected between biparietal diameter (BPD) (Pinteraction = 0.007), head circumference (Pinteraction = 0.026) at 16 weeks' gestation in the first trimester, BPD (Pinteraction = 0.015) at 24 weeks' gestation in the second trimester, BPD (Pinteraction = 0.014) at 31 weeks' gestation in the second trimester and BPD (Pinteraction = 0.035) at 37 weeks' gestation in the third trimester and fetal sex, and the strength of the association between the level of Al exposure and BPD was significantly stronger in female fetuses than in male fetuses. Furthermore, we observed three distinct trajectories of trimester-specific Al concentrations during pregnancy. Compared to participants with low-stable group of Al concentrations trajectory, high-stable group was associated with more decrease level of fetal growth parameters and birth size indicators.

Conclusion: Our study results reveal that Al might have harmful effects on fetal growth and birth size indicators, especially in female fetuses. Further study is required to examine our findings in other populations.

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来源期刊
CiteScore
12.10
自引率
5.90%
发文量
1234
审稿时长
88 days
期刊介绍: Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.
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