Sorcin：在癌症特征、抗药性和治疗机会方面的作用机制。

IF 2.8 4区医学 Q2 ONCOLOGY

Medical Oncology Pub Date : 2024-12-14 DOI:10.1007/s12032-024-02580-6

Sushmita Ghosh, Arpana Sharma, R Suresh Kumar, Vilas Nasare

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引用次数: 0

摘要

可溶性耐药相关钙结合蛋白（Sorcin）在肿瘤进展、血管生成、转移和多药耐药过程中起重要作用。Sorcin在不同癌症中的差异表达与关键的临床病理特征和生存结果显著相关，强调了其作为预后标志物的潜力。它对耐药癌症的参与进一步表明Sorcin是一个有希望的治疗靶点。本文综述了Sorcin在癌症中的作用机制、对耐药的贡献、临床相关性以及目前和新兴的将Sorcin靶向治疗转化为临床实践的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sorcin: mechanisms of action in cancer hallmarks, drug resistance and opportunities in therapeutics.

Soluble resistant related calcium binding protein (Sorcin) plays an important role in tumor progression, angiogenesis, metastasis, and multidrug resistance. Differential expression of Sorcin across different cancers significantly correlates with key clinicopathological characteristics and survival outcomes, underscoring its potential as a prognostic marker. Its involvement in drug-resistant cancers further advert Sorcin as a promising therapeutic target. This review summarizes the mechanistic role of Sorcin in cancer, its contribution to drug resistance, clinical relevance, and the current and emerging therapeutic approaches aimed at translating Sorcin-targeted therapies into clinical practice.

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来源期刊

Medical Oncology 医学-肿瘤学

CiteScore

4.20

自引率

2.90%

发文量

259

审稿时长

1.4 months

期刊介绍： Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.