纳米材料影响细胞间连接。

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science Pub Date : 2025-02-01 DOI:10.1016/j.cis.2024.103372

Jinping Wang , Guoying Zhang , Kuoran Xing , Baoteng Wang , Yanping Liu , Yuling Xue , Shankui Liu , David Tai Leong

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引用次数: 0

摘要

细胞-细胞连接对于维持组织完整性和调节广泛的生理过程至关重要。虽然细胞间连接的破坏可能导致病理状况，但它也提供了治疗干预的机会。纳米材料已经成为调节细胞-细胞连接的有前途的工具，为创新治疗提供了新的途径。在这篇综述中，我们提供了各种纳米材料与细胞-细胞连接相互作用的全面概述。我们讨论了它们的潜在机制，对细胞行为的异质性影响，以及应用纳米材料诱导细胞间连接破坏的治疗策略。此外，我们讨论了将这些策略转化为临床实践所涉及的挑战和机遇，并讨论了这一快速发展领域的未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Influencing inter-cellular junctions with nanomaterials

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Influencing inter-cellular junctions with nanomaterials

Cell-cell junctions are essential for maintaining tissue integrity and regulating a wide range of physiological processes. While the disruption of intercellular junctions may lead to pathological conditions, it also presents an opportunity for therapeutic interventions. Nanomaterials have emerged as promising tools for modulating cell-cell junctions, offering new avenues for innovative treatments. In this review, we provide a comprehensive overview of the various nanomaterials interaction with cell-cell junctions. We discussed their underlying mechanisms, heterogenous effects on cellular behavior, and the therapeutic strategies of applying nanomaterial-induced intercellular junction disruption. Additionally, we address the challenges and opportunities involved in translating these strategies into clinical practice and discuss future directions for this rapidly advancing field.

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.