急性病毒感染后人类精液中病毒持续存在的时间：系统综述。

IF 20.9 1区生物学 Q1 INFECTIOUS DISEASES

Lancet Microbe Pub Date : 2025-05-01 DOI:10.1016/j.lanmic.2024.101013

Caitlin Pley MB , Laura Jung MD , Nadra Nurdin MB , Tim Venkatesan MSc , Vasanth V Naidu MRCP , Rosemary James MB , Laura Kmentt MB , Isaac Florence MSc , Ellie Delight MSc , Christina Guo MD , Alex Paddy Abdel Salam DPhil

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引用次数: 0

摘要

急性感染后，病毒在人类精液中的持续存在会导致疾病的持续传播，或在疫情宣布结束后导致疾病复发。精液中的病毒持续存在会影响胚胎发育和男性生育能力，并影响药物和疫苗的研发。我们根据 PRISMA 指南对精液中的病毒持续存在进行了系统性回顾。在对 5 个数据库中的 29 739 篇文章进行筛选后，373 项原创研究被纳入本综述。有证据表明，在急性感染后，人类精液中可检测到 22 种病毒，其中包括具有流行潜力的病原体。除了整理迄今为止关于急性感染后精液中病毒检测的最大证据库外，本综述还报告了发病后病毒持续存在的最大值和中值（天数），以及精液中病毒的性传播和存活率的证据。最后，本综述提出了需要优先考虑的研究缺口，以指导对精液中病毒存留动态的进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Duration of viral persistence in human semen after acute viral infection: a systematic review

The persistence of viruses in human semen following acute infection can contribute to the ongoing transmission of a disease or cause resurgence after an outbreak has been declared ended. Viral persistence in semen affects embryonic development and male fertility, and the development of drugs and vaccines. We conducted a systematic review of viral persistence in semen in accordance with PRISMA guidelines. 373 original studies were included in this Review after screening 29 739 articles from five databases. Evidence was found of detection of 22 viruses in human semen following acute infection, including pathogens with pandemic potential. In addition to collating the largest evidence base to date on viral detection in semen following acute infection, this Review reports the maximal and median viral persistence (in days) after the onset of illness and evidence for sexual transmission and viability of the viruses in semen. Finally, the Review presents research gaps that need to be prioritised to guide further study of the dynamics of viral persistence in semen.

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来源期刊

Lancet Microbe Multiple-

CiteScore

27.20

自引率

0.80%

发文量

278

审稿时长

6 weeks

期刊介绍： The Lancet Microbe is a gold open access journal committed to publishing content relevant to clinical microbiologists worldwide, with a focus on studies that advance clinical understanding, challenge the status quo, and advocate change in health policy.