Guidelines for selection and application of kinetics models in bioproduction processes.

Biotechnology is widely used in bioproduction to transform waste into valuable products. A comprehensive understanding of the kinetics involved is crucial for optimizing system designs. In this review, we explore various kinetics models (e.g., the Gompertz, Logistic, Cone, first-order, Monod, and Andrews models) used in describing bioproduction processes. We focus on their interpretation and applications in microbial growth, bioproduct formation, substrate consumption, and the factors influencing bioproduction processes. We provide guidelines for selecting appropriate kinetics models, emphasizing their suitability for different kinetic processes under varying conditions. Additionally, we discuss the importance of statistical parameters in evaluating model performance. This review presents a framework for applying these models to effectively predict and optimize bioproduction systems.