莪术酮 A-N，莪术次生根茎中的倍半萜。

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-12-16 DOI:10.1016/j.phytochem.2024.114353

Lijia Chen , Juan Zou , Bingying Jiang , Peiran Li , Yiming Li , Liang Zhao , Fujiang Guo

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引用次数: 0

摘要

从姜黄文玉金次生根茎中分离到14个未描述的倍半萜，命名为姜黄aones A-N（1 ~ 14）和44个已知的倍半萜（15 ~ 58）。利用核磁共振光谱分析、高分辨率电喷雾质谱（hremsims）数据和电子圆二色性（ECD）光谱分析对1-14的结构和绝对构型进行了分析。其中，得到了5个具有过氧化物键的倍半萜（1-5），并讨论了连接过氧化物键的α-C与氧原子之间的化学位移变化。结果表明，化合物12和14在20、50和100 μM时表现出明显的拮抗作用，而化合物8、32、17和34表现出中至弱的拮抗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Curcumaones A-N, sesquiterpenes from the secondary rhizomes of Curcuma wenyujin

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Curcumaones A-N, sesquiterpenes from the secondary rhizomes of Curcuma wenyujin

Fourteen undescribed sesquiterpenes, named curcumaones A-N (1–14), as well as forty-four (15–58) known ones, were isolated from the secondary rhizomes of Curcuma wenyujin. The structures and absolute configurations of 1–14 were elucidated based on NMR spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data and electronic circular dichroism (ECD) spectral analysis. Among these, five sesquiterpenes with the peroxide linkage (1–5) were obtained and the change of chemical shift between the α-C connecting the peroxide linkage and the oxygen atom has been discussed. In addition, all the isolated compounds were evaluated for their agonistic effect on farnesoid X receptors (FXR) situated with human embryonic kidney (HEK) 293T cells and the results showed that compounds 12 and 14 exhibited a significant agonistic effect dose-dependently at 20, 50 and 100 μM, while 8, 32, 17 and 34 possessed moderate to weak agonistic effects.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.