骨微环境如何塑造转移前的龛位和转移。

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-12-13 DOI:10.1038/s43018-024-00854-6

Kailey N. Jackett, Alice T. Browne, Etan R. Aber, Miranda Clements, Rosandra N. Kaplan

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引用次数: 0

摘要

骨骼是经常发生转移的部位，矿化骨和骨髓环境的变化也会通过教育祖细胞支持转移扩散而为其他部位的转移提供条件。基质和免疫群体共同维持着组织复杂的骨龛，并在出现远处原发肿瘤和转移性疾病时发生失调。利用创新技术对促进转移扩散的骨龛进行研究，有可能有助于防止骨内转移和由骨介导的转移。在此，我们将回顾骨龛生物学的最新进展及其在癌症中的适应性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

How the bone microenvironment shapes the pre-metastatic niche and metastasis

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How the bone microenvironment shapes the pre-metastatic niche and metastasis

The bone is a frequent metastatic site, with changes in the mineralized bone and the bone marrow milieu that can also prime other sites for metastasis by educating progenitor cells to support metastatic spread. Stromal and immune populations cooperatively maintain the organizationally complex bone niches and are dysregulated in the presence of a distant primary tumor and metastatic disease. Interrogating the bone niches that facilitate metastatic spread using innovative technologies holds the potential to aid in preventing metastasis in and mediated by the bone. Here, we review recent advances in bone niche biology and its adaptations in the context of cancer. Kaplan and colleagues discuss adaptations in the bone environment in the context of cancer, reflect on advanced technologies to study these bone niches and summarize how a remodeled bone marrow milieu can prime other sites for metastasis.

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.