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IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2024-12-07 DOI:10.1016/j.jpsychires.2024.12.012

Amandine Luquiens, Thibault Mura, Alexandra Dereux, Patrice Louville, Hélène Donnadieu, Marie Bronnec, Amine Benyamina, Pascal Perney, Arnaud Carré

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引用次数: 0

摘要

情绪失调和冲动与酒精使用障碍（AUD）密切相关。本研究探讨了冲动性和情绪失调的作用，以及它们与成人可能患有的多动症（ADHD）在酒精相关生活质量（QoL）方面的相互作用。在这项观察性试验中，我们分析了随机TRAIN研究的数据，该研究比较了两种认知训练计划对2019年2月至2023年2月期间在法国5个中心戒毒的AUD患者的疗效，这些患者完成了儿童和成人ADHD筛查数据（WURS + ARSR，226人中有206人）。我们收集了有关AUD严重程度、年龄、性别、生活质量（AQoLS）、认知障碍（MoCA）、冲动行为（UPPS-P）和情绪失调（ERQ表达抑制子分数、DERS-冲动）的基线数据。我们对可能患有多动症和未患有多动症的患者进行了比较。我们通过冲动（UPPS-P 评分）、情绪调节（DERS-冲动）和表达抑制（ERQ 表达抑制子评分）对 AQoLS 总分（因变量）及其与 ADHD 的交互作用进行了多元线性回归，并对 MoCA、性别和年龄进行了调整。40名患者（19%）超过了多动症的筛查阈值。与无多动症的患者相比，酒精对他们生活质量的影响更大（57.3 (21.9) vs. 46.4 (19.6)，p = 0.002）。高冲动性和情绪失调都与较差的 QoL 显著相关。多动症与表达压抑有明显的交互作用，会加重酒精对 QoL 的影响（p = 0.04）。ADHD患者对强烈的情绪失调进行功能性补偿的尝试会降低 AUD 患者的 QoL。

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ADHD and alcohol: Emotional regulation efforts pay off in quality of life points.

The emotion dysregulation and impulsivity are highly associated with alcohol use disorder (AUD). This study explored the role of impulsivity and emotion dysregulation and the interaction with adult probable ADHD on alcohol-related quality of life (QoL). In this observational trial, we analyzed data from the randomized TRAIN study, which compared efficacy of two cognitive training programs in patients AUD recently detoxified at 5 centers in France from February 2019 to February 2023, and who completed child and adult ADHD screening data (WURS + ARSR, n = 206 of 226). We collected baseline data on AUD severity, age, sex, quality of life (AQoLS), cognitive impairment (MoCA), impulsive behavior (UPPS-P) and emotion dysregulation (ERQ expressive suppression subscore, DERS-impulse). Patients with probable and without ADHD were compared. We performed multiple linear regression explaining the total AQoLS score (dependent variable) by impulsivity (UPPS-P score), emotion regulation (DERS-impulse), and expressive suppression (ERQ expressive suppression subscore), and their interaction with ADHD, adjusted on MoCA, sex, age. Forty (19%) patients were above the screening threshold for ADHD. The impact of alcohol on QoL was greater in them than in those without ADHD (57.3 (21.9) vs. 46.4 (19.6), p = 0.002). High impulsivity and emotion dysregulation dimensions were both significantly associated with poorer QoL. ADHD interacted significantly with expressive suppression to worsen the impact of alcohol on QoL (p = 0.04). The dysfunctional attempts to compensate for the strong dysregulation of emotions in ADHD lowers QoL in AUD.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;