- Book学术

发布求助

文献互助智能选刊最新文献

IF 6.6 1区医学 Q1 OBSTETRICS & GYNECOLOGY

Fertility and sterility Pub Date : 2024-12-11 DOI:10.1016/j.fertnstert.2024.12.009

Hester Pastoor, Ellen Laan, Joop Laven, Stephanie Both

{"title":"Sexual response in women with Polycystic Ovary Syndrome: a case control study.","authors":"Hester Pastoor, Ellen Laan, Joop Laven, Stephanie Both","doi":"10.1016/j.fertnstert.2024.12.009","DOIUrl":null,"url":null,"abstract":"Objective: To study genital response and sexual arousal in women with and without PCOS and to assess associations with sex steroid levels.Design: This observational prospective case control study was conducted from March 2017 until March 2020.Subjects: Heterosexual women with (n=68) and without PCOS (n=67), aged 18-40 years, in a steady relationship and without any comorbidities.Exposure: All participants underwent an extensive medical and endocrine screening as well as assessment of genital blood flow (vaginal pulse amplitude (VPA)), assessed with photoplethysmography), and sexual arousal and affect (Likert scale questionnaire) in response to erotic and vibrotactile stimulation.Main outcome measures: Vaginal pulse amplitude, lubrication, subjective sexual arousal and affect.Results: There were no significant differences in genital blood flow response and self-reported lubrication between women with and without PCOS. After adjusting for confounders, women with PCOS did report significantly lower positive affect in the fantasy and vibrotactile condition compared to women without PCOS. Regression analyses adjusted for confounders showed only few and weak associations of sexual responses with androgen levels explaining only a maximum of 6% of variance in all models in women with and those without PCOS. The PCOS group showed only weak associations between subjective sexual arousal and DHEA (fantasy: β=1.719, P=0.049, Adj R2=0.020), and SHBG (fantasy: β=-1.728, P=0.020, Adj R2=0.044).Conclusion: Women with PCOS show similar genital sexual response and lubrication, but lower positive affect compared to women without PCOS, however, only few, and weak associations with androgen levels were found. Androgen levels are not indicative of genital response and subjective arousal. Sexual function should be discussed in clinical care and psychosexual counseling should be offered.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6000,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fertility and sterility","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.fertnstert.2024.12.009","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的研究患有和未患有多囊卵巢综合征的女性的生殖器反应和性唤起，并评估与性类固醇水平的关系：这项观察性前瞻性病例对照研究从 2017 年 3 月开始至 2020 年 3 月结束：患有和未患有多囊卵巢综合征的异性恋女性（68人）和未患有多囊卵巢综合征的异性恋女性（67人），年龄在18-40岁之间，关系稳定，无任何合并症：所有参与者均接受了广泛的医疗和内分泌筛查，并接受了生殖器血流（阴道脉搏振幅（VPA））评估（用光电压力计评估），以及对情色和振动刺激的性唤起和性影响（李克特量表问卷）：主要结果测量：阴道脉搏振幅、润滑、主观性唤醒和情感：结果：患有和未患有多囊卵巢综合症的女性在生殖器血流反应和自我报告的润滑度方面没有明显差异。在对混杂因素进行调整后，患有多囊卵巢综合症的女性在幻想和振动触觉条件下的积极情绪确实明显低于未患有多囊卵巢综合症的女性。对混杂因素进行调整后进行的回归分析表明，在所有模型中，患有和未患有多囊卵巢综合症的女性的性反应与雄激素水平之间的关联很少且很弱，最多只能解释 6% 的方差。多囊卵巢综合征组的主观性唤起与 DHEA（幻想：β=1.719，P=0.049，Adj R2=0.020）和 SHBG（幻想：β=-1.728，P=0.020，Adj R2=0.044）之间仅存在微弱关联：与无多囊卵巢综合症的女性相比，患有多囊卵巢综合症的女性表现出相似的生殖器性反应和润滑度，但积极情绪较低，然而，与雄激素水平的关联较少且较弱。雄激素水平并不代表生殖器反应和主观唤起。在临床护理中应讨论性功能问题，并提供性心理咨询。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Sexual response in women with Polycystic Ovary Syndrome: a case control study.

Objective: To study genital response and sexual arousal in women with and without PCOS and to assess associations with sex steroid levels.

Design: This observational prospective case control study was conducted from March 2017 until March 2020.

Subjects: Heterosexual women with (n=68) and without PCOS (n=67), aged 18-40 years, in a steady relationship and without any comorbidities.

Exposure: All participants underwent an extensive medical and endocrine screening as well as assessment of genital blood flow (vaginal pulse amplitude (VPA)), assessed with photoplethysmography), and sexual arousal and affect (Likert scale questionnaire) in response to erotic and vibrotactile stimulation.

Main outcome measures: Vaginal pulse amplitude, lubrication, subjective sexual arousal and affect.

Results: There were no significant differences in genital blood flow response and self-reported lubrication between women with and without PCOS. After adjusting for confounders, women with PCOS did report significantly lower positive affect in the fantasy and vibrotactile condition compared to women without PCOS. Regression analyses adjusted for confounders showed only few and weak associations of sexual responses with androgen levels explaining only a maximum of 6% of variance in all models in women with and those without PCOS. The PCOS group showed only weak associations between subjective sexual arousal and DHEA (fantasy: β=1.719, P=0.049, Adj R²=0.020), and SHBG (fantasy: β=-1.728, P=0.020, Adj R²=0.044).

Conclusion: Women with PCOS show similar genital sexual response and lubrication, but lower positive affect compared to women without PCOS, however, only few, and weak associations with androgen levels were found. Androgen levels are not indicative of genital response and subjective arousal. Sexual function should be discussed in clinical care and psychosexual counseling should be offered.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Fertility and sterility 医学-妇产科学

CiteScore

11.30

自引率

6.00%

发文量

1446

审稿时长

31 days

期刊介绍： Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.