IF 7.7 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Naomi Lejeune, Elke Rouxel, Christine Monfort, Hélène Tillaut, Florence Rouget, Nathalie Costet, Frank Giton, Éric Gaudreau, Fabrice Lainé, Ronan Garlantézec, Sylvaine Cordier, Cécile Chevrier, Charline Warembourg
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引用次数: 0

摘要

导言:虽然有许多研究探讨了产前暴露于全氟和多氟烷基物质(PFAS)对儿童肥胖的影响,但报告的结果并不一致,而且很少有研究整合了生物标记物。本研究旨在调查产前暴露于全氟烷基物质与 12 岁时心脏代谢健康参数之间的关系,同时考虑到青春期阶段:这项研究包括 394 对加入 PELAGIE 母婴队列(法国)的母婴。对脐带血中的 9 种 PFAS 进行了测量,孩子们在 12 岁时接受了临床检查。对人体测量、血液代谢指标和血压进行了测量,并利用这些指标建立了内部心脏代谢评分。在调整混杂因素并按性别和青春期阶段进行分层后,采用线性回归和定量G计算模型来评估个体和混合物中PFAS的影响:结果:产前暴露于全氟辛烷磺酸与 12 岁时的心脏代谢评分之间没有统计学意义上的关联。在初潮后的女孩中,全氟己烷磺酸(PFHxS)和全氟癸酸(PFDA)在统计学上与一些脂肪参数的下降有显著相关性(例如,体重指数 z 值:β [95%CI] = -0.37 [-0.67; -0.07]),同时也与低密度脂蛋白(LDL)和瘦素水平的下降有显著相关性。在全氟辛烷磺酸混合物中也观察到了类似的结果,在统计意义上,三足皮褶显著降低(β [95%CI] = -1.30 [(-2.54; -0.06)])。在特定亚组中观察到了孤立的关联,包括收缩压升高、胆固醇水平变化和脂肪连素水平降低:结论:没有明确证据表明产前接触全氟辛烷磺酸与青春期发育早期的心脏代谢健康之间存在关联。然而,在初潮后的女孩中,却观察到了 PFAS 与人体测量指标之间的反向关系。虽然有关青春期前青少年这一主题的文献很少,但这些结果表明,在这些关联中考虑性别和青春期阶段非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between prenatal exposure to PFAS and cardiometabolic health in preadolescents.

Introduction: While a number of studies have examined the effects of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) on childhood obesity, the results reported have been inconsistent and few studies have integrated biological markers. The aim of this study was to investigate the associations between prenatal exposure to PFAS and cardiometabolic health parameters at age 12, taking pubertal stage into consideration.

Method: This study included 394 mother-child pairs enrolled in the PELAGIE mother-child cohort (France). Nine PFAS were measured in umbilical cord blood, and the children attended a clinical examination at age 12. Anthropometry, blood metabolic markers, and blood pressure were measured and used to build an internal cardiometabolic score. Linear regression and Quantile G-computation models were used to evaluate individual and mixture PFAS effects, adjusting for confounders and stratifying by sex and pubertal stage.

Results: No statistically significant association was observed between prenatal exposure to PFAS and cardiometabolic score at age 12. In post-menarche girls, perfluorohexane sulfonate (PFHxS) and perfluorodecanoic acid (PFDA) were statistically significantly associated with a decrease in a number of adiposity parameters (e.g., Body mass index z-score: beta [95%CI] = -0.37 [-0.67; -0.07]), as well as a decrease in low-density lipoproteins (LDL) and leptin levels. Similar results were observed with PFAS mixture, with statistically significantly decreased tricipital skinfolds (beta [95%CI] = -1.30 [(-2.54;-0.06)]). Isolated associations, including higher systolic blood pressure, changes in cholesterol levels, and lower adiponectin levels were observed in specific subgroups.

Conclusion: There is no clear evidence of an association between prenatal exposure to PFAS and the cardiometabolic health at earlier stage of pubertal development. However, inverse associations between PFAS and anthropometric measures have been observed in post-menarche girls. While the literature on this topic is scarce in pre-adolescents, these results suggest the importance of considering sex and pubertal stage in these associations.

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来源期刊
Environmental Research
Environmental Research 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
12.60
自引率
8.40%
发文量
2480
审稿时长
4.7 months
期刊介绍: The Environmental Research journal presents a broad range of interdisciplinary research, focused on addressing worldwide environmental concerns and featuring innovative findings. Our publication strives to explore relevant anthropogenic issues across various environmental sectors, showcasing practical applications in real-life settings.
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