一种简单、精确、稳健的反相高效液相色谱-紫外法测定胶粘剂中聚乙烯吡咯烷酮的建立与验证

IF 1 4区 化学 Q4 CHEMISTRY, ANALYTICAL
Anand Gupta, Kanchan Nautiyal, Anubhav Saxena
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引用次数: 0

摘要

聚乙烯吡咯烷酮(PVP)有多种分子量和相关粘度,可根据所需应用特性进行选择。为估算粘合剂配方中聚乙烯吡咯烷酮 K-90 的含量,我们开发了一种简单、准确、稳健的反相液相色谱法,并随后进行了验证。采用 Zorbax Eclipse XDB C18 色谱柱,在波长为 200 nm 的紫外波长下进行分离并获得峰的最大响应。PVP 的检测限和定量限分别为 16.0 mg/L 和 50.0 mg/L。在 50.0 至 1000.0 mg/L 的浓度范围内,该方法的线性关系良好,相关系数为 0.999。该方法的特异性、线性、准确度、精密度、稳健性和耐用性均得到了验证,并成功地应用于胶水样品中PVP的测定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Development and Validation of a Simple, Precise, and Robust Reversed-Phase High-Performance Liquid Chromatography-Ultraviolet Method for the Determination of Polyvinylpyrrolidone in Adhesives

Development and Validation of a Simple, Precise, and Robust Reversed-Phase High-Performance Liquid Chromatography-Ultraviolet Method for the Determination of Polyvinylpyrrolidone in Adhesives

Polyvinylpyrrolidone (PVP) is available in a range of molecular weights and related viscosities that can be selected according to the desired application properties. A simple, accurate, and robust reversed-phase liquid chromatography method has been developed and subsequently validated for the estimation of polyvinylpyrrolidone K-90 in adhesive formulations. Separation and maximum response of the peak were obtained at UV a wavelength of 200 nm on a Zorbax Eclipse XDB C18 column. The limit of detection and limit of quantification of PVP were found to be 16.0 and 50.0 mg/L, respectively. The calibration curve showed good linearity over the concentration range of 50.0 to 1000.0 mg/L, with a correlation coefficient of 0.999. The proposed method was validated for specificity, linearity, accuracy, precision, robustness, and ruggedness, and successfully applied for the determination of PVP in glue samples.

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来源期刊
Journal of Analytical Chemistry
Journal of Analytical Chemistry 化学-分析化学
CiteScore
2.10
自引率
9.10%
发文量
146
审稿时长
13 months
期刊介绍: The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.
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