{"title":"一种简单、精确、稳健的反相高效液相色谱-紫外法测定胶粘剂中聚乙烯吡咯烷酮的建立与验证","authors":"Anand Gupta, Kanchan Nautiyal, Anubhav Saxena","doi":"10.1134/S1061934824701417","DOIUrl":null,"url":null,"abstract":"<p>Polyvinylpyrrolidone (<b>PVP</b>) is available in a range of molecular weights and related viscosities that can be selected according to the desired application properties. A simple, accurate, and robust reversed-phase liquid chromatography method has been developed and subsequently validated for the estimation of polyvinylpyrrolidone K-90 in adhesive formulations. Separation and maximum response of the peak were obtained at UV a wavelength of 200 nm on a Zorbax Eclipse XDB C18 column. The limit of detection and limit of quantification of PVP were found to be 16.0 and 50.0 mg/L, respectively. The calibration curve showed good linearity over the concentration range of 50.0 to 1000.0 mg/L, with a correlation coefficient of 0.999. The proposed method was validated for specificity, linearity, accuracy, precision, robustness, and ruggedness, and successfully applied for the determination of PVP in glue samples.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"79 12","pages":"1834 - 1843"},"PeriodicalIF":1.0000,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development and Validation of a Simple, Precise, and Robust Reversed-Phase High-Performance Liquid Chromatography-Ultraviolet Method for the Determination of Polyvinylpyrrolidone in Adhesives\",\"authors\":\"Anand Gupta, Kanchan Nautiyal, Anubhav Saxena\",\"doi\":\"10.1134/S1061934824701417\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Polyvinylpyrrolidone (<b>PVP</b>) is available in a range of molecular weights and related viscosities that can be selected according to the desired application properties. A simple, accurate, and robust reversed-phase liquid chromatography method has been developed and subsequently validated for the estimation of polyvinylpyrrolidone K-90 in adhesive formulations. Separation and maximum response of the peak were obtained at UV a wavelength of 200 nm on a Zorbax Eclipse XDB C18 column. The limit of detection and limit of quantification of PVP were found to be 16.0 and 50.0 mg/L, respectively. The calibration curve showed good linearity over the concentration range of 50.0 to 1000.0 mg/L, with a correlation coefficient of 0.999. The proposed method was validated for specificity, linearity, accuracy, precision, robustness, and ruggedness, and successfully applied for the determination of PVP in glue samples.</p>\",\"PeriodicalId\":606,\"journal\":{\"name\":\"Journal of Analytical Chemistry\",\"volume\":\"79 12\",\"pages\":\"1834 - 1843\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-12-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Analytical Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1061934824701417\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Analytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1061934824701417","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Development and Validation of a Simple, Precise, and Robust Reversed-Phase High-Performance Liquid Chromatography-Ultraviolet Method for the Determination of Polyvinylpyrrolidone in Adhesives
Polyvinylpyrrolidone (PVP) is available in a range of molecular weights and related viscosities that can be selected according to the desired application properties. A simple, accurate, and robust reversed-phase liquid chromatography method has been developed and subsequently validated for the estimation of polyvinylpyrrolidone K-90 in adhesive formulations. Separation and maximum response of the peak were obtained at UV a wavelength of 200 nm on a Zorbax Eclipse XDB C18 column. The limit of detection and limit of quantification of PVP were found to be 16.0 and 50.0 mg/L, respectively. The calibration curve showed good linearity over the concentration range of 50.0 to 1000.0 mg/L, with a correlation coefficient of 0.999. The proposed method was validated for specificity, linearity, accuracy, precision, robustness, and ruggedness, and successfully applied for the determination of PVP in glue samples.
期刊介绍:
The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.